J
Janeric Seidegård
Researcher at AstraZeneca
Publications - 55
Citations - 3950
Janeric Seidegård is an academic researcher from AstraZeneca. The author has contributed to research in topics: Glutathione transferase activity & Epoxide hydrolase. The author has an hindex of 23, co-authored 55 publications receiving 3887 citations. Previous affiliations of Janeric Seidegård include Lund University.
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Journal Article
Metabolic gene polymorphism frequencies in control populations.
Seymour Garte,Laura Gaspari,A.-K. Alexandrie,Christine B. Ambrosone,Herman Autrup,Judith L. Autrup,H. Baranova,L. Bathum,Simone Benhamou,Paolo Boffetta,C. Bouchardy,K. Breskvar,J. Brockmöller,Ingolf Cascorbi,Margie L. Clapper,Christiane Coutelle,Ann K. Daly,Marco Dell'Omo,Vita Dolzan,C.M. Dresler,Anthony A. Fryer,Aage Haugen,David W. Hein,Allan Hildesheim,Ari Hirvonen,L.L. Hsieh,Magnus Ingelman-Sundberg,Ivan Kalina,Daehee Kang,Masahiro Kihara,Chikako Kiyohara,Pierre Kremers,Philip Lazarus,Loic Le Marchand,Maria Celeste Lechner,E.M.M. van Lieshout,Stephanie J. London,Johannes J. Manni,Christine Maugard,S. Morita,Valle Nazar-Stewart,K. Noda,Yoshio Oda,Fritz F. Parl,Roberta Pastorelli,I. Persson,Wilbert H.M. Peters,Agneta Rannug,Timothy R. Rebbeck,Angela Risch,L. Roelandt,Marjorie Romkes,David Ryberg,Salagovic J,Bernadette Schoket,Janeric Seidegård,Peter G. Shields,Edith Sim,D. Sinnet,Richard C. Strange,Isabelle Stücker,Haruhiko Sugimura,Jordi To-Figueras,Paolo Vineis,M.C. Yu,Emanuela Taioli +65 more
TL;DR: Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes in the human population were determined.
Journal ArticleDOI
Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.
TL;DR: This article measured human liver mRNA levels by using mouse and human cDNA clones that encode class-mu and class-alpha glutathione transferase (GT; EC 2.5.1.18) mRNA levels.
Journal ArticleDOI
Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study
Janeric Seidegård,Ronald W. Pero,Melvin M. Markowitz,George C. Roush,Daniel G. Miller,Edward J. Beattie +5 more
TL;DR: It is concluded that the gene expressing class Mu isoenzymes may be a host determinant of genetic susceptibility to lung cancer among smokers.
Journal ArticleDOI
A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer.
TL;DR: It was concluded that the gene expressing this isozyme(s) may be a host genetic determinant of susceptibility to lung cancer in smokers.
Journal ArticleDOI
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
Simone Benhamou,Won Jin Lee,A.-K. Alexandrie,Paolo Boffetta,Christine Bouchardy,Dorota Butkiewicz,Jürgen Brockmöller,Margie L. Clapper,Ann K. Daly,Vita Dolzan,Jean G. Ford,Laura Gaspari,Aage Haugen,Ari Hirvonen,Kirsti Husgafvel-Pursiainen,Magnus Ingelman-Sundberg,Ivan Kalina,Masahiro Kihara,Pierre Kremers,Loic Le Marchand,Stephanie J. London,Valle Nazar-Stewart,Masako Onon-Kihara,Agneta Rannug,Marjorie Romkes,David Ryberg,Janeric Seidegård,Peter G. Shields,Richard C. Strange,Isabelle Stücker,Jordi To-Figueras,Paul Brennan,Emanuela Taioli +32 more
TL;DR: A pooled analysis of the original data of about 9500 subjects involved in 21 case-control studies from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC) data set was performed to assess the role of GSTM1 genotype as a modifier of the effect of smoking on lung cancer risk with adequate power.