P
Philip Lazarus
Researcher at Washington State University Spokane
Publications - 241
Citations - 14085
Philip Lazarus is an academic researcher from Washington State University Spokane. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 62, co-authored 222 publications receiving 12283 citations. Previous affiliations of Philip Lazarus include Washington State University & Northeast Forestry University.
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Journal ArticleDOI
Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.
Mia Hashibe,Paul Brennan,Shu Chun Chuang,Stefania Boccia,Xavier Castellsagué,Chu Chen,Maria Paula Curado,Luigino Dal Maso,Alexander W. Daudt,Eleonora Fabianova,Leticia Fernandez,Victor Wünsch-Filho,Silvia Franceschi,Richard B. Hayes,Rolando Herrero,Karl T. Kelsey,Karl T. Kelsey,Sergio Koifman,Carlo La Vecchia,Philip Lazarus,Fabio Levi,Juan Lence,Dana Mates,Elena Matos,Ana Maria Menezes,Michael D. McClean,Joshua E. Muscat,José Eluf-Neto,Andrew F. Olshan,Mark P. Purdue,Peter Rudnai,Stephen M. Schwartz,Elaine M. Smith,Erich M. Sturgis,Neonilia Szeszenia-Dabrowska,Renato Talamini,Qingyi Wei,Deborah M. Winn,Oxana Shangina,Agnieszka Pilarska,Zuo-Feng Zhang,Gilles Ferro,Julien Berthiller,Paolo Boffetta +43 more
TL;DR: It is confirmed that the joint effect between tobacco and alcohol use is greater than multiplicative on head and neck cancer risk, however, a substantial proportion of head and head cancers cannot be attributed to tobacco or alcohol use, particularly for oral cavity cancer and for head andneck cancer among women and among young-onset cases.
Journal Article
Metabolic gene polymorphism frequencies in control populations.
Seymour Garte,Laura Gaspari,A.-K. Alexandrie,Christine B. Ambrosone,Herman Autrup,Judith L. Autrup,H. Baranova,L. Bathum,Simone Benhamou,Paolo Boffetta,C. Bouchardy,K. Breskvar,J. Brockmöller,Ingolf Cascorbi,Margie L. Clapper,Christiane Coutelle,Ann K. Daly,Marco Dell'Omo,Vita Dolzan,C.M. Dresler,Anthony A. Fryer,Aage Haugen,David W. Hein,Allan Hildesheim,Ari Hirvonen,L.L. Hsieh,Magnus Ingelman-Sundberg,Ivan Kalina,Daehee Kang,Masahiro Kihara,Chikako Kiyohara,Pierre Kremers,Philip Lazarus,Loic Le Marchand,Maria Celeste Lechner,E.M.M. van Lieshout,Stephanie J. London,Johannes J. Manni,Christine Maugard,S. Morita,Valle Nazar-Stewart,K. Noda,Yoshio Oda,Fritz F. Parl,Roberta Pastorelli,I. Persson,Wilbert H.M. Peters,Agneta Rannug,Timothy R. Rebbeck,Angela Risch,L. Roelandt,Marjorie Romkes,David Ryberg,Salagovic J,Bernadette Schoket,Janeric Seidegård,Peter G. Shields,Edith Sim,D. Sinnet,Richard C. Strange,Isabelle Stücker,Haruhiko Sugimura,Jordi To-Figueras,Paolo Vineis,M.C. Yu,Emanuela Taioli +65 more
TL;DR: Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes in the human population were determined.
Journal ArticleDOI
Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium
Mia Hashibe,Paul Brennan,Simone Benhamou,Xavier Castellsagué,Chu Chen,Maria Paula Curado,Luigino Dal Maso,Alexander W. Daudt,Eleonora Fabianova,Victor Wünsch-Filho,Silvia Franceschi,Richard B. Hayes,Rolando Herrero,Sergio Koifman,Carlo La Vecchia,Philip Lazarus,Fabio Levi,Dana Mates,Elena Matos,Ana M. B. Menezes,Joshua E. Muscat,José Eluf-Neto,Andrew F. Olshan,Peter Rudnai,Stephen M. Schwartz,Elaine M. Smith,Erich M. Sturgis,Neonilia Szeszenia-Dabrowska,Renato Talamini,Qingyi Wei,Deborah M. Winn,David Zaridze,Witold Zatonski,Zuo-Feng Zhang,Julien Berthiller,Paolo Boffetta +35 more
TL;DR: The results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.
Journal ArticleDOI
Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study
Robert Carreras-Torres,Mattias Johansson,Philip C Haycock,Kaitlin H Wade,Caroline L Relton,Richard M. Martin,Richard M. Martin,George Davey Smith,Demetrius Albanes,Melinda C. Aldrich,Angeline S. Andrew,Susanne M. Arnold,Heike Bickeböller,Stig E. Bojesen,Hans Brunnström,Jonas Manjer,Irene Brüske,Neil E. Caporaso,Chu Chen,David C. Christiani,W. Jay Christian,Jennifer A. Doherty,Eric J. Duell,John K. Field,Michael P.A. Davies,Michael W. Marcus,Gary E. Goodman,Kjell Grankvist,Aage Haugen,Yun-Chul Hong,Lambertus A. Kiemeney,Erik H.F.M. van der Heijden,Peter Kraft,Mikael Johansson,Stephen Lam,Maria Teresa Landi,Philip Lazarus,Loic Le Marchand,Geoffrey Liu,Olle Melander,Sungshim L. Park,Gad Rennert,Angela Risch,Eric B. Haura,Ghislaine Scelo,David Zaridze,Anush Mukeriya,Milan Savic,Jolanta Lissowska,Beata Swiatkowska,Vladimir Janout,Ivana Holcatova,Dana Mates,Matthew B. Schabath,Hongbing Shen,Adonina Tardón,M. Dawn Teare,Penella J. Woll,Ming-Sound Tsao,Xifeng Wu,Jian-Min Yuan,Rayjean J. Hung,Christopher I. Amos,James D. McKay,Paul Brennan +64 more
TL;DR: The results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma, and the latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior.
Journal ArticleDOI
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
James D. McKay,Rayjean J. Hung,Younghun Han,Xuchen Zong,Robert Carreras-Torres,David C. Christiani,Neil E. Caporaso,Mattias Johansson,Xiangjun Xiao,Yafang Li,Jinyoung Byun,Alison M. Dunning,Karen A. Pooley,David C. Qian,Xuemei Ji,Geoffrey Liu,Maria Timofeeva,Stig E. Bojesen,Stig E. Bojesen,Stig E. Bojesen,Xifeng Wu,Loic Le Marchand,Demetrios Albanes,Heike Bickeböller,Melinda C. Aldrich,William S. Bush,Adonina Tardón,Gad Rennert,M. Dawn Teare,John K. Field,Lambertus A. Kiemeney,Philip Lazarus,Aage Haugen,Stephen Lam,Matthew B. Schabath,Angeline S. Andrew,Hongbing Shen,Yun Chul Hong,Jian-Min Yuan,Pier Alberto Bertazzi,Angela Cecilia Pesatori,Yuanqing Ye,Nancy Diao,Li Su,Ruyang Zhang,Yonathan Brhane,Natasha B. Leighl,Jakob S Johansen,Anders Mellemgaard,Walid Saliba,Christopher A. Haiman,Lynne R. Wilkens,Ana Fernández-Somoano,Guillermo Fernández-Tardón,Henricus F. M. van der Heijden,Jin Hee Kim,Juncheng Dai,Zhibin Hu,Michael P.A. Davies,Michael W. Marcus,Hans Brunnström,Jonas Manjer,Olle Melander,David C. Muller,Kim Overvad,Antonia Trichopoulou,Rosario Tumino,Jennifer A. Doherty,Matt P Barnett,Chu Chen,Gary E. Goodman,Angela Cox,Fiona Taylor,Penella J. Woll,Irene Brüske,H-Erich Wichmann,H-Erich Wichmann,Judith Manz,Thomas Muley,Angela Risch,Albert Rosenberger,Kjell Grankvist,Mikael Johansson,Frances A. Shepherd,Ming-Sound Tsao,Susanne M. Arnold,Eric B. Haura,Ciprian Bolca,Ivana Holcatova,Vladimir Janout,Milica Kontic,Jolanta Lissowska,Anush Mukeria,Simona Ognjanovic,Tadeusz M Orlowski,Ghislaine Scelo,Beata Swiatkowska,David Zaridze,Per Bakke,Vidar Skaug,Shanbeh Zienolddiny,Eric J. Duell,Lesley M. Butler,Woon-Puay Koh,Yu-Tang Gao,Richard S. Houlston,John McLaughlin,Victoria L. Stevens,Philippe Joubert,Maxime Lamontagne,David C. Nickle,Ma'en Obeidat,Wim Timens,Bin Zhu,Lei Song,Linda Kachuri,María Soler Artigas,María Soler Artigas,Martin D. Tobin,Martin D. Tobin,Louise V. Wain,Louise V. Wain,Thorunn Rafnar,Thorgeir E. Thorgeirsson,Gunnar W Reginsson,Kari Stefansson,Dana B. Hancock,Laura J. Bierut,Margaret R. Spitz,Nathan C. Gaddis,Sharon M. Lutz,Fangyi Gu,Eric O. Johnson,Ahsan Kamal,Claudio W. Pikielny,Dakai Zhu,Sara Lindstroem,Xia Jiang,Rachel F. Tyndale,Rachel F. Tyndale,Georgia Chenevix-Trench,Jonathan Beesley,Yohan Bossé,Stephen J. Chanock,Paul Brennan,Maria Teresa Landi,Christopher I. Amos +146 more
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.