J
Jason Corbin
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 27
Citations - 3595
Jason Corbin is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cytokine & Suppressor of cytokine signaling 1. The author has an hindex of 17, co-authored 25 publications receiving 3268 citations. Previous affiliations of Jason Corbin include University of Melbourne & Cooperative Research Centre.
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Journal ArticleDOI
SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine
Warren S. Alexander,Robyn Starr,Robyn Starr,Jennifer Eve Fenner,Clare L. Scott,Clare L. Scott,Emanuela Handman,Naomi S. Sprigg,Naomi S. Sprigg,Jason Corbin,Jason Corbin,Ann L Cornish,Ann L Cornish,Rima Darwiche,Catherine M Owczarek,Thomas W.H. Kay,Nicos A. Nicola,Nicos A. Nicola,Paul J. Hertzog,Donald Metcalf,Donald Metcalf,Douglas J. Hilton,Douglas J. Hilton +22 more
TL;DR: It is indicated that SOCS1 is a key modulator of IFNgamma action, allowing the protective effects of this cytokine to occur without the risk of associated pathological responses.
Journal ArticleDOI
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.
James A Rickard,James A Rickard,Joanne A. O’Donnell,Joanne A. O’Donnell,Joseph M Evans,Joseph M Evans,Najoua Lalaoui,Najoua Lalaoui,Ashleigh R Poh,Ashleigh R Poh,TeWhiti Rogers,James E Vince,James E Vince,Kate E. Lawlor,Kate E. Lawlor,Robert L Ninnis,Robert L Ninnis,Holly Anderton,Holly Anderton,Cathrine Hall,Cathrine Hall,Sukhdeep K Spall,Sukhdeep K Spall,Toby J. Phesse,Toby J. Phesse,Helen E. Abud,Louise H. Cengia,Louise H. Cengia,Jason Corbin,Jason Corbin,Sandra Mifsud,Sandra Mifsud,Ladina Di Rago,Ladina Di Rago,Donald Metcalf,Donald Metcalf,Matthias Ernst,Matthias Ernst,Grant Dewson,Grant Dewson,Andrew W. Roberts,Andrew W. Roberts,Warren S. Alexander,Warren S. Alexander,James M. Murphy,James M. Murphy,Paul G Ekert,Paul G Ekert,Seth L. Masters,Seth L. Masters,David L. Vaux,David L. Vaux,Ben A. Croker,Ben A. Croker,Ben A. Croker,Motti Gerlic,Motti Gerlic,Motti Gerlic,John Silke,John Silke +59 more
TL;DR: A key function for RIPK1 is revealed in inhibiting necroptosis and, thereby, a role in limiting, not only promoting, inflammation is revealed.
Journal ArticleDOI
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
Sandra E. Nicholson,David P De Souza,Louis Fabri,Jason Corbin,Tracy A. Willson,Jian-Guo Zhang,Anabel Silva,Maria Asimakis,Alison Farley,Andrew D. Nash,Donald Metcalf,Douglas J. Hilton,Nicos A. Nicola,Manuel Baca +13 more
TL;DR: Data suggest that the mechanism by which SOCS-3 inhibited signaling in cells transfected with a chimeric receptor containing the wild-type gp130 intracellular domain depends on recruitment to the phosphorylated gp130 receptor, and that some of the negative regulatory roles previously attributed to the tyrosine phosphatase SHP-2 might in fact be caused by the action of SOCS.
Journal ArticleDOI
Platelets kill intraerythrocytic malarial parasites and mediate survival to infection
Brendan J. McMorran,Vikki M. Marshall,Carolyn A. de Graaf,Carolyn A. de Graaf,Karen E. Drysdale,Meriam Shabbar,Gordon K. Smyth,Jason Corbin,Warren S. Alexander,Simon J. Foote +9 more
TL;DR: Results indicate a protective function for platelets in the early stages of erythrocytic infection distinct from their role in cerebral malaria.
Journal ArticleDOI
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
James A Rickard,Holly Anderton,Nima Etemadi,Ueli Nachbur,Maurice Darding,Nieves Peltzer,Najoua Lalaoui,Kate E. Lawlor,Hannah K. Vanyai,Cathrine Hall,Aleks Bankovacki,Lahiru Gangoda,W. Wei-Lynn Wong,Jason Corbin,Chunzi Huang,Edward S. Mocarski,James M. Murphy,Warren S. Alexander,Anne K. Voss,David L. Vaux,William J. Kaiser,Henning Walczak,John Silke +22 more
TL;DR: Unexpectedly, Sharpin, Ripk3 and Casp8 triple deficiency caused perinatal lethality, providing unexpected insights into the developmental importance of SHARPIN.