J
Jason Fixler
Researcher at Lawrence Berkeley National Laboratory
Publications - 7
Citations - 797
Jason Fixler is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Anemia & Piebaldism. The author has an hindex of 5, co-authored 7 publications receiving 687 citations.
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Journal ArticleDOI
Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia
Michael R. DeBaun,Mae O. Gordon,Robert C. McKinstry,Michael J. Noetzel,Desirée A. White,Sharada A. Sarnaik,Emily Riehm Meier,Thomas H. Howard,Suvankar Majumdar,Baba Inusa,Paul Telfer,Melanie Kirby-Allen,Timothy L. McCavit,Annie Kamdem,Gladstone Airewele,Gerald M. Woods,Brian Berman,Julie A. Panepinto,Beng Fuh,Janet L. Kwiatkowski,Allison A. King,Jason Fixler,Melissa Rhodes,Alexis A. Thompson,Mark E. Heiny,Rupa Redding-Lallinger,Fenella J. Kirkham,Natalia Dixon,Corina E. Gonzalez,Karen Kalinyak,Charles T. Quinn,John J. Strouse,J. P. Miller,Harold P Lehmann,Michael A. Kraut,William S. Ball,Deborah Hirtz,James F. Casella +37 more
TL;DR: Regular blood-transfusion therapy significantly reduced the incidence of the recurrence of cerebral infarct in children with sickle cell anemia.
Journal ArticleDOI
Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure.
Michael R. DeBaun,Sharada A. Sarnaik,Mark Rodeghier,Caterina P. Minniti,Thomas H. Howard,Rathi V. Iyer,Baba Inusa,Paul Telfer,Melanie Kirby-Allen,Charles T. Quinn,Françoise Bernaudin,Gladstone Airewele,Gerald M. Woods,Julie A. Panepinto,Beng Fuh,Janet K. Kwiatkowski,Allison A. King,Melissa Rhodes,Alexis A. Thompson,Mark E. Heiny,Rupa Redding-Lallinger,Fenella J. Kirkham,Hernan Sabio,Corina E. Gonzalez,Suzanne Saccente,Karen Kalinyak,John J. Strouse,Jason Fixler,Mae O. Gordon,J. Phillip Miller,Michael J. Noetzel,Rebecca Ichord,James F. Casella +32 more
TL;DR: Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI.
Journal ArticleDOI
Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology.
Lydie Da Costa,Gil Tchernia,Philippe Gascard,Annie Lo,Joerg J Meerpohl,Charlotte M. Niemeyer,Joel-Anne Chasis,Jason Fixler,Narla Mohandas +8 more
TL;DR: The present findings enable us to document the nucleolar localization signals in RPS19 and help define the phenotypic consequences of some mutations in R PS19 in DBA.
Journal ArticleDOI
Ribosomal protein S19 expression during erythroid differentiation.
Lydie Da Costa,Goutham Narla,Thiebaut Noel Willig,Luanne L. Peters,Marilyn Parra,Jason Fixler,Gil Tchernia,Narla Mohandas +7 more
TL;DR: By Northern blot and Western blot analyses of murine splenic erythroblasts infected with the anemia-inducing strain Friend virus (FAV cells), RPS19 mRNA and protein expression were shown to decrease during terminal erythroid differentiation.
Journal ArticleDOI
Silent cerebral infarction, income, and grade retention among students with sickle cell anemia
Allison A. King,Mark Rodeghier,Julie A. Panepinto,John J. Strouse,James F. Casella,Charles T. Quinn,Michael M. Dowling,Sharada A. Sarnaik,Alexis A. Thompson,Gerald M. Woods,Caterina P. Minniti,Rupa Redding-Lallinger,Melanie Kirby-Allen,Fenella J. Kirkham,Robert C. McKinstry,Michael J. Noetzel,Desirée A. White,Janet K. Kwiatkowski,Thomas H. Howard,Karen Kalinyak,Baba Inusa,Melissa Rhodes,Mark E. Heiny,Ben Fuh,Jason Fixler,Mae O. Gordon,Michael R. DeBaun +26 more
TL;DR: Among students with sickle cell anemia, household per capita income is associated with grade retention, whereas the presence of a silent cerebral infarct is not.