Mary Ellen Digan

TL;DR: a4−/− mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells, and a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo is revealed.

TL;DR: The in vivo potency of the genetically engineered immunotoxins was assayed in the transgenic heterozygote mouse, tgepsilon 600, in which the T-cells express human CD3epsilon as well as murine CD3EPsilon, and potency increased 10-fold over the chemically conjugated immunotoxin, UCHT1-CRM9 and the monovalent A-dmDT390-sFv.

TL;DR: It is demonstrated that PTPN14 downregulation can phenocopy YAP activation in mammary epithelial cells and synergize with YAP to induce oncogenic transformation and appear to be dispensable for the negative regulation of endogenous YAP.

TL;DR: A broad correlation appears to exist between binding affinity and immunotoxin potency in immunotoxins in which scFvs from different antibodies are fused to the same toxin domain (DT or PE), however, no correlation between affinity and potency appears to exists when different toxin domains are combined with the same scFv antibody domain.

TL;DR: In this paper, a DT-based immunotoxin fusion protein was described and shown in the specification and drawings, which can be expressed in bacterial, yeast, or mammalian cells.