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Andrew F. Powers
Researcher at University of Washington
Publications - 17
Citations - 1944
Andrew F. Powers is an academic researcher from University of Washington. The author has contributed to research in topics: Kinetochore microtubule & Autophagy. The author has an hindex of 10, co-authored 17 publications receiving 1650 citations. Previous affiliations of Andrew F. Powers include University of California, Davis & Genomics Institute of the Novartis Research Foundation.
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Journal ArticleDOI
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
William E. Dowdle,Beat Nyfeler,Jane Nagel,Robert Elling,Shanming Liu,Ellen Triantafellow,Suchithra Menon,Zuncai Wang,Ayako Honda,Gwynn Pardee,John Cantwell,Catherine Luu,Ivan Cornella-Taracido,Edmund Harrington,Peter Fekkes,Hong Lei,Qing Fang,Mary Ellen Digan,Debra Burdick,Andrew F. Powers,Stephen B. Helliwell,Simon D’Aquin,Julie Bastien,Henry Wang,Dmitri Wiederschain,Jenny Kuerth,Philip Bergman,David Schwalb,Jason R. Thomas,Savuth Ugwonali,Fred Harbinski,John A. Tallarico,Christine D. Wilson,Vic E. Myer,Jeffery A. Porter,Dirksen E. Bussiere,Peter Finan,Mark Labow,Xiaohong Mao,Lawrence G. Hamann,Brendan D. Manning,Reginald Valdez,Thomas B. Nicholson,Markus Schirle,Mark Knapp,Erin P. Keaney,Leon Murphy +46 more
TL;DR: a4−/− mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells, and a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo is revealed.
Journal ArticleDOI
Tension directly stabilizes reconstituted kinetochore-microtubule attachments
Bungo Akiyoshi,Krishna K. Sarangapani,Andrew F. Powers,Christian R. Nelson,Steve L. Reichow,Hugo Arellano-Santoyo,Hugo Arellano-Santoyo,Tamir Gonen,Jeffrey A. Ranish,Charles L. Asbury,Sue Biggins +10 more
TL;DR: It is proposed that tension selectively stabilizes proper kinetochore–microtubule attachments in vivo through a combination of direct mechanical stabilization and tension-dependent phosphoregulation.
Journal ArticleDOI
The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion
Andrew F. Powers,Andrew D. Franck,Daniel R. Gestaut,Jeremy Cooper,Beth Gracyzk,Ronnie Wei,Linda Wordeman,Trisha N. Davis,Charles L. Asbury +8 more
TL;DR: These findings demonstrate how an ensemble of Ndc80 complexes may provide the combination of plasticity and strength that allows kinetochores to maintain load-bearing tip attachments during both microtubule assembly and disassembly.
Journal ArticleDOI
The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement.
TL;DR: An in vitro motility assay is developed where beads coated with pure recombinant Dam1 complex were bound to the tips of individual dynamic MTs, demonstrating how the Dam1complex may contribute directly to MT-driven chromosome movement.
Journal ArticleDOI
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.
Weijun Shen,Brandon Taylor,Qihui Jin,Van Nguyen-Tran,Shelly Meeusen,You-Qing Zhang,Anwesh Kamireddy,Austin De Swafford,Andrew F. Powers,John P Walker,John Lamb,Badry Bursalaya,Michael DiDonato,George Harb,Minhua Qiu,Christophe M. Filippi,Lisa Deaton,Carolina N. Turk,Wilma L. Suarez-Pinzon,Yahu Liu,Xueshi Hao,Tingting Mo,Shanshan Yan,Jing-Jing Li,Ann E. Herman,Bernhard J. Hering,Tao Wu,H. Martin Seidel,Peter McNamara,Richard Glynne,Bryan Laffitte +30 more
TL;DR: The feasibility of treating diabetes with an oral therapy to restore β-cell mass is supported, a tractable pathway for future drug discovery efforts is highlighted, and Dyrk1a is highlighted as the key molecular target.