J
Jason W. H. Wong
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 189
Citations - 8329
Jason W. H. Wong is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 46, co-authored 175 publications receiving 7382 citations. Previous affiliations of Jason W. H. Wong include University of New South Wales & University College Dublin.
Papers
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Journal ArticleDOI
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.
Teru Hideshima,James E. Bradner,Jason W. H. Wong,Dharminder Chauhan,Paul G. Richardson,Stuart L. Schreiber,Kenneth C. Anderson +6 more
TL;DR: It is demonstrated that tubacin combined with bortezomib mediates significant anti-MM activity, providing the framework for clinical evaluation of combined therapy to improve patient outcome in MM.
Journal ArticleDOI
Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation
Justin J.-L. Wong,Justin J.-L. Wong,William Ritchie,William Ritchie,Olivia A. Ebner,Matthias Selbach,Jason W. H. Wong,Yizhou Huang,Dadi Gao,Dadi Gao,Natalia Pinello,Natalia Pinello,María Jesús González González,María Jesús González González,Kinsha Baidya,Kinsha Baidya,Annora Thoeng,Annora Thoeng,Teh-Liane Khoo,Teh-Liane Khoo,Charles G. Bailey,Charles G. Bailey,Jeff Holst,Jeff Holst,John E.J. Rasko,John E.J. Rasko,John E.J. Rasko +26 more
TL;DR: Bioinformatic analyses of transcriptomic and proteomic data of normal white blood cell differentiation reveal IR as a physiological mechanism of gene expression control and establish that IR coupled with NMD is a conserved mechanism in normal granulopoiesis.
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A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
Helen H.N. Yan,Hoi Cheong Siu,Simon Law,Siu Lun Ho,Sarah S K Yue,Wai Yin Tsui,D Chan,April S. Chan,Stephanie Ma,Ka-On Lam,Sina Bartfeld,Alice H Y Man,Bernard C H Lee,Annie S Y Chan,Jason W. H. Wong,Priscilla S.W. Cheng,Anthony K W Chan,Jiangwen Zhang,Jue Shi,Xiaodan Fan,Dora Lai-Wan Kwong,Tak W. Mak,Siu Tsan Yuen,Siu Tsan Yuen,Hans Clevers,Suet Yi Leung +25 more
TL;DR: A primary gastric cancer organoid biobank that comprises normal, dysplastic, cancer, and lymph node metastases from 34 patients, including detailed whole-exome and transcriptome analysis, provides a useful resource for studying both cancer cell biology and precision cancer therapy.
Journal ArticleDOI
Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy
TL;DR: This prospective study was performed to identify the best test for assessment of the adequacy of hepatic functional reserve in patients with HCC before hepatectomy.
Journal ArticleDOI
Preoperative endoscopic drainage for malignant obstructive jaundice.
Edward C. S. Lai,Francis P. T. Mok,ST Fan,Chung Mau Lo,Kent Man Chu,Chi-Leung Liu,Jason W. H. Wong +6 more
TL;DR: Despite the improvement of liver function, routine application of endoscopic drainage had no demonstrable benefit and was indicated only when early surgery is not feasible, especially for patients with distal obstruction.