J
Javier G. De Gaudenzi
Researcher at National Scientific and Technical Research Council
Publications - 18
Citations - 2036
Javier G. De Gaudenzi is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Gene expression & Gene. The author has an hindex of 11, co-authored 17 publications receiving 1925 citations. Previous affiliations of Javier G. De Gaudenzi include National University of General San Martín.
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Journal ArticleDOI
The genome of the kinetoplastid parasite, Leishmania major.
Alasdair Ivens,Christopher S. Peacock,Elizabeth A. Worthey,Lee Murphy,Gautam Aggarwal,Matthew Berriman,Ellen Sisk,Marie-Adèle Rajandream,Ellen Adlem,Rita Aert,Atashi Anupama,Zina Apostolou,Philip Attipoe,Nathalie Bason,Christopher Bauser,Alfred Beck,Stephen M. Beverley,Gabriella Bianchettin,K. Borzym,G. Bothe,Carlo V. Bruschi,Carlo V. Bruschi,Matt Collins,Eithon Cadag,Laura Ciarloni,Christine Clayton,Richard M.R. Coulson,Ann Cronin,Angela K. Cruz,Robert L. Davies,Javier G. De Gaudenzi,Deborah E. Dobson,Andreas Duesterhoeft,Gholam Fazelina,Nigel Fosker,Alberto C.C. Frasch,Audrey Fraser,Monika Fuchs,Claudia Gabel,Arlette Goble,André Goffeau,David Harris,Christiane Hertz-Fowler,Helmut Hilbert,David Horn,Yiting Huang,Sven Klages,Andrew J Knights,Michael Kube,Natasha Larke,Lyudmila Litvin,Angela Lord,Tin Louie,Marco A. Marra,David Masuy,Keith R. Matthews,Shulamit Michaeli,Jeremy C. Mottram,Silke Müller-Auer,Heather Munden,Siri Nelson,Halina Norbertczak,Karen Oliver,Susan O'Neil,Martin Pentony,Thomas M. Pohl,Claire Price,Bénédicte Purnelle,Michael A. Quail,Ester Rabbinowitsch,Richard Reinhardt,Michael A. Rieger,Joel Rinta,Johan Robben,Laura Robertson,Jeronimo C. Ruiz,Simon Rutter,David L. Saunders,Melanie Schäfer,Jacquie Schein,David C. Schwartz,Kathy Seeger,Amber Seyler,Sarah Sharp,Heesun Shin,Dhileep Sivam,Rob Squares,Steve Squares,Valentina Tosato,Christy Vogt,Guido Volckaert,Rolf Wambutt,T. Warren,Holger Wedler,John Woodward,Shiguo Zhou,Wolfgang Zimmermann,Deborah F. Smith,Jenefer M. Blackwell,Kenneth Stuart,Kenneth Stuart,Bart Barrell,Peter J. Myler,Peter J. Myler +103 more
TL;DR: The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Tritryp genomes suggest that the mechanisms regulating RNA polymerase II–directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling.
Journal ArticleDOI
RNA-Binding Domain Proteins in Kinetoplastids: a Comparative Analysis
TL;DR: Just 3 RRM proteins which appear to be conserved at the primary sequence level throughout eukaryotic evolution are revealed: poly(A) binding protein, the rRNA-processing protein MRD1, and the nuclear cap binding protein.
Journal ArticleDOI
Recruitment of mRNAs to cytoplasmic ribonucleoprotein granules in trypanosomes
TL;DR: It is suggested that trypanosomes make use of mRNA granules for transient transcript protection as a strategy to cope with periods of starvation that they have to face during their complex life cycles.
Journal ArticleDOI
Gene expression regulation in trypanosomatids.
TL;DR: In the present chapter, particular characteristics of gene expression in the so-called TriTryp parasites are focused on: Trypanosoma cruzi, Trypenosoma brucei and Leishmania major.
Journal ArticleDOI
RNA-binding proteins and mRNA turnover in trypanosomes.
TL;DR: Along with the detection of an active exosome, decapping activities and a regulated 3' to 5' exonuclease activity stimulated by AREs, these results suggest that modulation of mRNA stability is essential in trypanosomes.