J
Javier Seravalli
Researcher at University of Nebraska–Lincoln
Publications - 72
Citations - 3530
Javier Seravalli is an academic researcher from University of Nebraska–Lincoln. The author has contributed to research in topics: Active site & Carbon monoxide dehydrogenase. The author has an hindex of 31, co-authored 69 publications receiving 2822 citations. Previous affiliations of Javier Seravalli include Lawrence Berkeley National Laboratory & Albert Einstein College of Medicine.
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Journal ArticleDOI
A Ni-Fe-Cu Center in a Bifunctional Carbon Monoxide Dehydrogenase/ Acetyl-CoA Synthase
TL;DR: A metallocofactor containing iron, sulfur, copper, and nickel has been discovered in the enzyme carbon monoxide dehydrogenase/acetyl-CoA (coenzyme A) synthase from Moorella thermoacetica and suggests a newly discovered role for copper in biology.
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Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.
Ishraq Alim,Joseph T. Caulfield,Yingxin Chen,Vivek Swarup,Vivek Swarup,Daniel H. Geschwind,Elena Ivanova,Javier Seravalli,Youxi Ai,Lauren H Sansing,Emma J. Ste.Marie,Robert J. Hondal,Sushmita Mukherjee,John W. Cave,Botir T. Sagdullaev,Saravanan S. Karuppagounder,Rajiv R. Ratan +16 more
TL;DR: Systemic administration of a brain-penetrant selenopeptide activates homeostatic transcription to inhibit cell death and improves function when delivered after hemorrhagic or ischemic stroke.
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Rapid and efficient electrocatalytic CO2/CO interconversions by Carboxydothermus hydrogenoformans CO dehydrogenase I on an electrode.
TL;DR: The Ni-containing carbon monoxide dehydrogenase I from Carboxydothermus hydrogenoformans adsorbed on a pyrolytic graphite “edge” electrode catalyzes rapid CO2/CO interconversions at the thermodynamic potential.
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Biosynthesis and Reactivity of Cysteine Persulfides in Signaling
Pramod Kumar Yadav,Michael V. Martinov,Victor Vitvitsky,Javier Seravalli,Rudolf Wedmann,Milos R. Filipovic,Ruma Banerjee +6 more
TL;DR: In vitro data are consistent with the absence of an observable increase in protein persulfidation in cells in response to exogenous cystine and evidence for the formation of polysulfides under these conditions.
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Dietary selenium affects host selenoproteome expression by influencing the gut microbiota
Marina V. Kasaikina,Marina V. Kasaikina,Marina A. Kravtsova,Byung Cheon Lee,Byung Cheon Lee,Javier Seravalli,Daniel A. Peterson,Jens Walter,Ryan Legge,Andrew K. Benson,Dolph L. Hatfield,Vadim N. Gladyshev,Vadim N. Gladyshev +12 more
TL;DR: The data show that dietary selenium affects both composition of the intestinal microflora and colonization of the gastrointestinal tract, which, in turn, influence the host Selenium status and selenoproteome expression by influencing the gut microbiota.