S
Saravanan S. Karuppagounder
Researcher at Cornell University
Publications - 46
Citations - 3151
Saravanan S. Karuppagounder is an academic researcher from Cornell University. The author has contributed to research in topics: Neuroprotection & Oxidative stress. The author has an hindex of 19, co-authored 42 publications receiving 2164 citations. Previous affiliations of Saravanan S. Karuppagounder include Council of Scientific and Industrial Research & Lebanese American University.
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Journal ArticleDOI
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.
Ishraq Alim,Joseph T. Caulfield,Yingxin Chen,Vivek Swarup,Vivek Swarup,Daniel H. Geschwind,Elena Ivanova,Javier Seravalli,Youxi Ai,Lauren H Sansing,Emma J. Ste.Marie,Robert J. Hondal,Sushmita Mukherjee,John W. Cave,Botir T. Sagdullaev,Saravanan S. Karuppagounder,Rajiv R. Ratan +16 more
TL;DR: Systemic administration of a brain-penetrant selenopeptide activates homeostatic transcription to inhibit cell death and improves function when delivered after hemorrhagic or ischemic stroke.
Journal ArticleDOI
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Saravanan S. Karuppagounder,John T. Pinto,Hui Xu,Huan-Lian Chen,M. Flint Beal,Gary E. Gibson +5 more
TL;DR: The concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against beta-amyloid plaque formation and oxidative stress is supported.
Journal ArticleDOI
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Sama F. Sleiman,Jeffrey Henry,Rami Al-Haddad,Lauretta El Hayek,Edwina Abou Haidar,Thomas Stringer,Devyani Ulja,Saravanan S. Karuppagounder,Edward B. Holson,Rajiv R. Ratan,Ipe Ninan,Moses V. Chao +11 more
TL;DR: An endogenous mechanism to explain how physical exercise leads to the induction of BDNF is revealed, and electrophysiological measurements indicate that β-hydroxybutyrate causes an increase in neurotransmitter release, which is dependent upon the TrkB receptor.
Journal ArticleDOI
Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.
Marietta Zille,Saravanan S. Karuppagounder,Yingxin Chen,Peter J. Gough,John Bertin,Joshua N. Finger,Teresa A. Milner,Elizabeth A. Jonas,Rajiv R. Ratan +8 more
TL;DR: It is proposed that ferroptosis or necroptotic signaling induced by lysed blood is sufficient to reach a threshold of death that leads to neuronal necrosis and that inhibition of either of these pathways can bring cells below that threshold to survival.
Journal ArticleDOI
N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.
Saravanan S. Karuppagounder,Lauren Alin,Yingxin Chen,David Brand,Megan W. Bourassa,Kristen Dietrich,Cassandra M. Wilkinson,Colby A. Nadeau,Amit Kumar,Steve Perry,John T. Pinto,Victor M. Darley-Usmar,Stephanie C. Sanchez,Ginger L. Milne,Domenico Praticò,Theodore R. Holman,S. Thomas Carmichael,Giovanni Coppola,Frederick Colbourne,Rajiv R. Ratan +19 more
TL;DR: The efficacy and mechanism of action of NAC is examined in rodent models of hemorrhagic stroke and it is shown that NAC acts as a “redox modulatory” agent in these models.