Jean-Bosco Tagne

TL;DR: This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.

TL;DR: An initial map of yeast's transcriptional regulatory code is constructed by identifying the sequence elements that are bound by regulators under various conditions and that are conserved among Saccharomyces species.

TL;DR: In this article, the authors measured genomewide binding locations for 30 damage-related transcription factors (TFs) after exposure of yeast to methyl-methanesulfonate (MMS).

TL;DR: Combinatorial regulation by Adr1 and Cat8, two transcription factors that act during glucose depletion, is analyzed by combining genome-wide expression and genome- wide binding data, providing a comprehensive analysis of the direct, indirect, and combinatorial requirements for these two global transcription factors.

TL;DR: In this xenograft mouse model of melanoma, nanoemulsion suspensions of DAC are more efficacious in the treatment and prevention of tumor growth.