Jean-Christophe Leroux

TL;DR: Clear evidence is provided that liposomes with a transmembrane pH gradient are able to change the pharmacokinetics and pharmacodynamics of diltiazem and its metabolite and confirmed their potential as efficient detoxifying nanocarriers.

TL;DR: Results indicate that less invasive surgery prevents lymphatic decompensation and reveal the development and maturation of collateral lymphatic vessels after extensive surgical trauma, which reroute the flow of lymph towards a different LN.

TL;DR: The decreased elafin expression in the small intestine of patients with active CD, the reduction of 33-mer peptide deamidation by elaf in vitro, coupled to the barrier enhancing and anti-inflammatory effects observed in gluten-sensitive mice, suggest that this molecule may have pathophysiological and therapeutic importance in wheat-related disorders.

TL;DR: "nano" creates both opportunities and challenges for targeted drug delivery, which are critically discussed in both in vitro and in vivo settings in this contribution.

TL;DR: An in vivo demonstration that modification of a protein with a polymer of appropriate architecture can impart low immunogenicity, with a commensurably low loss of therapeutic activity.