Jean-Claude Tabet

TL;DR: This review deals with strengths, limitations and future trends in the identification of signals highlighted by API-MS-based metabolomics, covering the identification process from the determination of the molecular mass and/or its elemental composition to the confirmation of structural hypotheses.

TL;DR: New technical developments for the direct tissue analysis of peptides with ionic liquid made of matrix mixtures and a new outlook on peptide tissue profiling by MS, characterization of compounds from tissue slices, and MALDI-MS high-quality imaging are presented.

TL;DR: In this article, protein and lipid modifications of several infant formulas, as well as pasteurized and UHT milk samples were evaluated, and the levels of secondary lipid oxidation products (malondialdehyde and hexanal), proteins modified by early (furosine, measurement of protein glycation) and advanced (carboxymethyllysine) Maillard reactions, and oxidized and crosslinked proteins (protein carbonyls, dityrosine, lysinoalanine) were measured.

TL;DR: Liquid chromatography coupled with tandem mass spectrometry provides a sensitive, specific, and accurate absolute quantification of Erbitux, a human:murine chimeric mAb used for the treatment of colorectal cancer and is a potential alternative for pharmacokinetic evaluation of mAbs during clinical development.

TL;DR: MccE492m is the first member of a new class of antimicrobial peptides carrying a siderophore-like post-translational modification and showing potent activity, which the authors term siderophile-peptides.