C
Carlos Afonso
Researcher at University of Rouen
Publications - 218
Citations - 4608
Carlos Afonso is an academic researcher from University of Rouen. The author has contributed to research in topics: Mass spectrometry & Ion-mobility spectrometry. The author has an hindex of 30, co-authored 194 publications receiving 3737 citations. Previous affiliations of Carlos Afonso include University of Paris & Centre national de la recherche scientifique.
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Journal ArticleDOI
Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease
Elodie Quévrain,Marie-Anne Maubert,Christophe Michon,Florian Chain,Florian Chain,Rodrigue Marquant,Rodrigue Marquant,Rodrigue Marquant,Julien Tailhades,Julien Tailhades,Julien Tailhades,Sylvie Miquel,Sylvie Miquel,Ludovic Carlier,Ludovic Carlier,Ludovic Carlier,Luis G. Bermúdez-Humarán,Luis G. Bermúdez-Humarán,Bénédicte Pigneur,Bénédicte Pigneur,Olivier Lequin,Olivier Lequin,Olivier Lequin,Pascale Kharrat,Pascale Kharrat,Ginette Thomas,Ginette Thomas,Dominique Rainteau,Camille Aubry,Camille Aubry,N. Breyner,N. Breyner,Carlos Afonso,Solange Lavielle,Solange Lavielle,Solange Lavielle,Jean-Pierre Grill,Jean-Pierre Grill,Gérard Chassaing,Gérard Chassaing,Gérard Chassaing,Jean-Marc Chatel,Jean-Marc Chatel,Germain Trugnan,Ramnik J. Xavier,P. Langella,P. Langella,Harry Sokol,Philippe Seksik +48 more
TL;DR: A 15 kDa protein with anti-inflammatory properties is produced by F. prausnitzii, a commensal bacterium involved in CD pathogenesis, and is able to inhibit the NF-κB pathway in intestinal epithelial cells and to prevent colitis in an animal model.
Journal ArticleDOI
Recommendations for reporting ion mobility Mass Spectrometry measurements
Valérie Gabelica,Alexandre A. Shvartsburg,Carlos Afonso,Perdita E. Barran,Justin L. P. Benesch,Christian Bleiholder,Michael T. Bowers,Aivett Bilbao,Matthew F. Bush,J. Larry Campbell,Iain D. G. Campuzano,Tim J. Causon,Brian H. Clowers,Colin S. Creaser,Edwin De Pauw,Johann Far,Francisco Fernandez-Lima,John C. Fjeldsted,Kevin Giles,Michael Groessl,Christopher J. Hogan,Stephan Hann,Hugh I. Kim,Ruwan T. Kurulugama,Jody C. May,John A. McLean,Kevin Pagel,Keith Richardson,Mark E. Ridgeway,Frédéric Rosu,Frank Sobott,Konstantinos Thalassinos,Stephen J. Valentine,Thomas Wyttenbach +33 more
TL;DR: A guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values.
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Dissection of proteolytic 18O labeling: endoprotease-catalyzed 16O-to-18O exchange of truncated peptide substrates.
TL;DR: It is proposed that proteolytic 18O labeling can be advantageously decoupled from protein digestion, and endoproteases can be used in a separate step to 18O2-code peptides for comparative studies after proteolysis has taken place.
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Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity.
Xavier Thomas,Delphine Destoumieux-Garzón,Jean Peduzzi,Carlos Afonso,Alain Blond,Nicolas Birlirakis,Christophe Goulard,Lionel Dubost,Robert Thai,Jean-Claude Tabet,Sylvie Rebuffat +10 more
TL;DR: MccE492m is the first member of a new class of antimicrobial peptides carrying a siderophore-like post-translational modification and showing potent activity, which the authors term siderophile-peptides.
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Omics-based strategies in precision medicine: Toward a paradigm shift in inborn errors of metabolism investigations
TL;DR: In this paper, the authors present state-of-the-art multi-omics data analysis strategies in a clinical context and the challenges of omics-based biomarker translation are discussed.