J
Jean-Michel Fustin
Researcher at Kyoto University
Publications - 39
Citations - 2494
Jean-Michel Fustin is an academic researcher from Kyoto University. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 20, co-authored 36 publications receiving 2000 citations. Previous affiliations of Jean-Michel Fustin include University of Aberdeen & University of Manchester.
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Journal ArticleDOI
RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
Jean-Michel Fustin,Masao Doi,Yoshiaki Yamaguchi,Hayashi Hida,Shinichi Nishimura,Minoru Yoshida,Takayuki Isagawa,Masaki Suimye Morioka,Hideaki Kakeya,Ichiro Manabe,Hitoshi Okamura +10 more
TL;DR: It is reported that inhibition of transmethylation reactions elongates the circadian period and methylation inhibition causes widespread changes in the transcription of the RNA processing machinery, associated with m(6)A-RNA methylation.
Journal ArticleDOI
Ancestral TSH mechanism signals summer in a photoperiodic mammal.
Elodie A. Hanon,Gerald A. Lincoln,Jean-Michel Fustin,Hugues Dardente,Mireille Masson-Pévet,Peter J. Morgan,David G. Hazlerigg +6 more
TL;DR: Melatonin acts directly on anterior-pituitary cells, and these then relay the photoperiodic message back into the hypothalamus to control neuroendocrine output, which provides the missing link between the pineal melatonin signal and thyroid-dependent seasonal biology.
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Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag
Yoshiaki Yamaguchi,Toru Suzuki,Yasutaka Mizoro,Hiroshi Kori,Kazuki Okada,Yulin Chen,Jean-Michel Fustin,Fumiyoshi Yamazaki,Naoki Mizuguchi,Jing Zhang,Xin Dong,Gozoh Tsujimoto,Yasushi Okuno,Masao Doi,Hitoshi Okamura,Hitoshi Okamura +15 more
TL;DR: Pharmacological blockade of V1a and V1b in the SCN of wild-type mice resulted in accelerated recovery from jet lag, which highlights the potential of vasopressin signaling as a therapeutic target for management of circadian rhythm misalignment, such as jet lag and shift work.
Journal ArticleDOI
Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus
Masao Doi,Atsushi Ishida,Akiko Miyake,Miho Sato,Rie Komatsu,Fumiyoshi Yamazaki,Ikuo Kimura,Soken Tsuchiya,Hiroshi Kori,Hiroshi Kori,Kazuyuki Seo,Yoshiaki Yamaguchi,Masahiro Matsuo,Jean-Michel Fustin,Rina Tanaka,Yasuko Santo,Hiroyuki Yamada,Yukari Takahashi,Michihiro Araki,Kazuki Nakao,Shinichi Aizawa,Masaki Kobayashi,Karl Obrietan,Gozoh Tsujimoto,Hitoshi Okamura,Hitoshi Okamura +25 more
TL;DR: The amount of RGS16 (regulator of G protein signalling 16), a protein known to inactivate Gαi, increases at a selective circadian time to allow time-dependent activation of intracellular cyclic AMP signalling in the SCN.
Journal ArticleDOI
CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.
Rajesh Narasimamurthy,Sabrina R. Hunt,Yining Lu,Jean-Michel Fustin,Hitoshi Okamura,Carrie L. Partch,Carrie L. Partch,Daniel B. Forger,Jae Kyoung Kim,David M. Virshup,David M. Virshup +10 more
TL;DR: A comprehensive biochemical and biophysical analysis of mouse PER2 (mPER2) priming phosphorylation is performed and it is demonstrated that CK1δ/ε is indeed the priming kinase and the extreme carboxyl terminus of CK1 as a key regulator of circadian timing is implicate.