Jeffrey M. Weiss

TL;DR: It is shown that mice from the Collaborative Cross panel of recombinant inbred mice exhibit distinct disease phenotypes after mouse-adapted Ebola virus infection, suggesting this panel of mice could prove valuable for preliminary screens of candidate therapeutics and vaccines.

TL;DR: Compared models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome CoV infection, revealing similarities and differences in strategies to control the interferon and innate immune response.

TL;DR: A major expansion of NHPRTR is described by adding 10.1 billion fragments of tissue-specific RNA-seq data, such that 88% of the reads align to human reference sequences, allowing the full list of expression abundance across all tissues for each species to be computed.

TL;DR: A large-scale RNA-Seq data and analysis infrastructure is described, the NHP reference transcriptome resource, which presently hosts data from 12 species of primates and is to be expanded to 15 species/subspecies spanning great apes, old world monkeys, new world monkeys and prosimians.

TL;DR: The first application to the authors' knowledge of next-generation sequencing to the analysis of RNA from a CD4+ T cell line infected with intact HIV is reported, providing insights into alternative viral RNA splice events and the expression of noncoding RNAs, including microRNA host genes.