S
Sheng Li
Researcher at Cornell University
Publications - 27
Citations - 4652
Sheng Li is an academic researcher from Cornell University. The author has contributed to research in topics: Epigenetics & Haematopoiesis. The author has an hindex of 19, co-authored 27 publications receiving 3675 citations. Previous affiliations of Sheng Li include University of Washington & University of Connecticut Health Center.
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Journal ArticleDOI
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
Altuna Akalin,Matthias Kormaksson,Sheng Li,Francine E. Garrett-Bakelman,Maria E. Figueroa,Ari Melnick,Christopher E. Mason +6 more
TL;DR: An R package that rapidly analyzes genome-wide cytosine epigenetic profiles from high-throughput methylation and Hydroxymethylation sequencing experiments is described, which includes functions for clustering, sample quality visualization, differential methylation analysis and annotation features, thus automating and simplifying many of the steps for discerning statistically significant bases or regions of DNAmethylation.
Journal ArticleDOI
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
Zhenqiang Su,Paweł P. Łabaj,Sheng Li,Jean Thierry-Mieg,Danielle Thierry-Mieg,Wei Shi,Charles Wang,Gary P. Schroth,Robert Setterquist,John F. Thompson,Wendell D. Jones,Wenzhong Xiao,Wenzhong Xiao,Weihong Xu,Roderick V. Jensen,Reagan Kelly,Joshua Xu,Ana Conesa,Cesare Furlanello,Hanlin Gao,Huixiao Hong,Nadereh Jafari,Stan Letovsky,Yang Liao,Fei Lu,Edward J. Oakeley,Zhiyu Peng,Craig A. Praul,Javier Santoyo-Lopez,Andreas Scherer,Tieliu Shi,Gordon K. Smyth,Frank Staedtler,Peter Sykacek,Xin Xing Tan,E. Aubrey Thompson,Jo Vandesompele,May D. Wang,Jian Wang,Russell D. Wolfinger,Jiri Zavadil,Jiri Zavadil,Scott S. Auerbach,Wenjun Bao,Hans Binder,Thomas M. Blomquist,Murray H. Brilliant,Pierre R. Bushel,Weimin Cai,Jennifer G. Catalano,Ching-Wei Chang,Tao Chen,Geng Chen,Rong Chen,Marco Chierici,Tzu Ming Chu,Djork-Arné Clevert,Youping Deng,Adnan Derti,Viswanath Devanarayan,Zirui Dong,Joaquín Dopazo,Tingting Du,Hong Fang,Yongxiang Fang,Mario Fasold,Anita Fernandez,Matthias Fischer,Pedro Furió-Tarí,James C. Fuscoe,Florian Caimet,Stan Gaj,Jorge Gandara,Huan Gao,Weigong Ge,Yoichi Gondo,Binsheng Gong,Meihua Gong,Zhuolin Gong,Bridgett Green,Chao Guo,Lei Guo,Li Wu Guo,James Hadfield,Jan Hellemans,Sepp Hochreiter,Meiwen Jia,Min Jian,Charles D. Johnson,Suzanne Kay,Jos C. S. Kleinjans,Samir Lababidi,Shawn Levy,Quan Zhen Li,Li Li,Peng Li,Yan Li,Haiqing Li,Jianying Li,Shiyong Li,Simon Lin,Francisco Javier López,Xin Lu,Heng Luo,Xiwen Ma,Joseph Meehan,Dalila B. Megherbi,Nan Mei,Bing Mu,Baitang Ning,Akhilesh Pandey,Javier Pérez-Florido,Roger Perkins,Ryan Peters,John H. Phan,Mehdi Pirooznia,Feng Qian,Tao Qing,Lucille Rainbow,Philippe Rocca-Serra,Laure Sambourg,Susanna-Assunta Sansone,Scott Schwartz,Ruchir R. Shah,Jie Shen,Todd M. Smith,Oliver Stegle,Nancy Stralis-Pavese,Elia Stupka,Yutaka Suzuki,Lee Thomas Szkotnicki,Matthew Tinning,Bimeng Tu,Joost H.M. van Delft,Alicia Vela-Boza,Elisa Venturini,Stephen J. Walker,Liqing Wan,Wei Wang,Jinhui Wang,Jun Wang,Jun Wang,Eric D. Wieben,James C. Willey,Po Yen Wu,Jiekun Xuan,Yong Yang,Zhan Ye,Ye Yin,Ying Yu,Yate Ching Yuan,John Zhang,Ke Zhang,Wenqian Zhang,Wenwei Zhang,Yanyan Zhang,Chen Zhao,Yuanting Zheng,Yiming Zhou,Paul Zumbo,Weida Tong,David P. Kreil,David P. Kreil,Christopher E. Mason,Leming Shi +164 more
TL;DR: The complete SEQC data sets, comprising >100 billion reads, provide unique resources for evaluating RNA-seq analyses for clinical and regulatory settings, and measurement performance depends on the platform and data analysis pipeline, and variation is large for transcript-level profiling.
Journal ArticleDOI
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Omar Abdel-Wahab,Jie Gao,Mazhar Adli,Anwesha Dey,Thomas Trimarchi,Young Rock Chung,Cem Kuscu,Todd Hricik,Delphine Ndiaye-Lobry,Lindsay M. LaFave,Richard Koche,Richard Koche,Alan H. Shih,Olga A. Guryanova,Eunhee Kim,Sheng Li,Suveg Pandey,Joseph Y. Shin,Leon Telis,Jinfeng Liu,Parva K. Bhatt,Sebastien Monette,Xinyang Zhao,Christopher E. Mason,Christopher Y. Park,Bradley E. Bernstein,Bradley E. Bernstein,Iannis Aifantis,Ross L. Levine,Ross L. Levine +29 more
TL;DR: Loss of Asxl1 results in myelodysplastic syndrome, whereas concomitant deletion of Tet2 restores HSC self-renewal and triggers a more severe disease phenotype distinct from that seen in single-gene knockout mice.
Journal ArticleDOI
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
Sheng Li,Francine E. Garrett-Bakelman,Stephen S. Chung,Mathijs A. Sanders,Todd Hricik,Franck Rapaport,Jay P. Patel,Richard Dillon,Priyanka Vijay,Anna L. Brown,Alexander E. Perl,Joy Cannon,Lars Bullinger,Selina M. Luger,Michael Becker,Ian D. Lewis,Ian D. Lewis,Ian D. Lewis,Luen Bik To,Ruud Delwel,Bob Löwenberg,Hartmut Döhner,Konstanze Döhner,Monica L. Guzman,Duane C. Hassane,Gail J. Roboz,David Grimwade,Peter J. M. Valk,Richard J D'Andrea,Richard J D'Andrea,Martin Carroll,Christopher Y. Park,Donna Neuberg,Ross L. Levine,Ari Melnick,Christopher E. Mason +35 more
TL;DR: It is observed that epigenetic allele burden is linked to inferior outcome and varies considerably during disease progression, and genetic and epigenetic heterogeneity can occur with distinct kinetics likely to affect the biological and clinical features of tumors.
Journal ArticleDOI
The Pivotal Regulatory Landscape of RNA Modifications
Sheng Li,Christopher E. Mason +1 more
TL;DR: Both labile and permanent modifications, from simple methylation to complex transcript alteration (RNA editing and intron retention) are examined; the models for their processing are detailed; and remaining questions in the field of the epitranscriptome are highlighted.