J
Jeffrey T. Chapman
Researcher at Cleveland Clinic
Publications - 28
Citations - 2839
Jeffrey T. Chapman is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Lymphangioleiomyomatosis & Lung transplantation. The author has an hindex of 17, co-authored 26 publications receiving 2436 citations. Previous affiliations of Jeffrey T. Chapman include Yale University & Veterans Health Administration.
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Journal ArticleDOI
Efficacy and safety of sirolimus in lymphangioleiomyomatosis.
Francis X. McCormack,Yoshikazu Inoue,Joel Moss,Lianne G. Singer,Charlie Strange,Koh Nakata,Alan F. Barker,Jeffrey T. Chapman,Mark L. Brantly,James M. Stocks,Kevin K. Brown,Joseph P. Lynch,Hilary J. Goldberg,Lisa R. Young,Lisa R. Young,Brent W. Kinder,Gregory P. Downey,Gregory P. Downey,Eugene J. Sullivan,Thomas V. Colby,Roy T. McKay,Marsha M. Cohen,Leslie L. Korbee,Angelo M. Taveira-DaSilva,Hye-Seung Lee,Jeffrey P. Krischer,Bruce C. Trapnell,Bruce C. Trapnell +27 more
TL;DR: In patients with LAM, sirolimus stabilized lung function, reduced serum VEGF-D levels, and was associated with a reduction in symptoms and improvement in quality of life.
Journal ArticleDOI
The NHLBI lymphangioleiomyomatosis registry: characteristics of 230 patients at enrollment.
Jay H. Ryu,Joel Moss,Gerald J. Beck,Jar Chi Lee,Kevin K. Brown,Jeffrey T. Chapman,Geraldine A. Finlay,Eric J. Olson,Stephen J. Ruoss,Janet R. Maurer,Thomas A. Raffin,Hannah Peavy,Kevin McCarthy,Angelo M. Taveira-DaSilva,Francis X. McCormack,Nilo A. Avila,Rosamma DeCastro,Susan S. Jacobs,Mario Stylianou,Barry L. Fanburg +19 more
TL;DR: The age range of women afflicted with pulmonary lymphangioleiomyomatosis is broader than previously appreciated and the degree of pulmonary function can be quite variable, with one-third of subjects having normal spirometry at enrollment into this registry.
Journal ArticleDOI
Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial
Ganesh Raghu,Rachel Million-Rousseau,Adele Morganti,Loïc Perchenet,Juergen Behr,Nicole S L Goh,Allan R. Glanville,Michael Musk,Peter Hopkins,Dale Lien,Christopher T. Chan,J. D. Rolf,Pearce G. Wilcox,P. G. Cox,Hélène Manganas,Vincent Cottin,Dominique Valeyre,B. Walleart,S. Andreas,Claus Neurohr,Andreas Guenther,N. Schönfeld,Andrea Koch,Mordechai R. Kramer,R. Breuer,I. Ben-Dov,G. Fink,Yehuda Schwarz,Carlo Albera,Marco Confalonieri,Cesare Saltini,Sergio Harari,M. Flezar,M. Greenblatt,G. J. Ras,Ferran Morell,José Luis Álvarez-Sala,Antonio Xaubet,A. Sueiro,M. J. Linares,Magnus Sköld,Oya Kayacan,Nesrin Mogulkoc,Andrew L. Chan,Jeffrey T. Chapman,Joseph Parambil,N. Ettinger,Jeffrey A. Golden,Keith C. Meyer,Jeffrey J. Swigris,Gordon L. Yung,Danielle Antin-Ozerkis,P. K. Mohabir,Lewis J. Wesselius,J.A. De Andrade,Francis Cordova,Zeenat Safdar,M. Wencel +57 more
TL;DR: Long-term exposure to macitentan was well tolerated with a similar, low incidence of elevated hepatic aminotransferases in each treatment group, and the primary objective was not met.
Journal ArticleDOI
Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management
Francis X. McCormack,Nishant Gupta,Geraldine R. Finlay,Lisa R. Young,Angelo M. Taveira-Da Silva,Connie G. Glasgow,Wendy K. Steagall,Simon R. Johnson,Steven A. Sahn,Jay H. Ryu,Charlie Strange,Kuniaki Seyama,Eugene J. Sullivan,Robert M. Kotloff,Gregory P. Downey,Jeffrey T. Chapman,MeiLan K. Han,Jeanine D'Armiento,Yoshikazu Inoue,Elizabeth P. Henske,John J. Bissler,Thomas V. Colby,Brent W. Kinder,Kathryn A. Wikenheiser-Brokamp,Kevin K. Brown,Jean F. Cordier,Cristopher A. Meyer,Vincent Cottin,Jan Brozek,Karen Smith,Kevin C. Wilson,Joel Moss +31 more
TL;DR: These guidelines provide recommendations for the diagnosis and treatment of patients with LAM, which included recommendations for sirolimus treatment and vascular endothelial growth factor D testing and recommendations against doxycycline and hormonal therapy.
Journal ArticleDOI
Carbon monoxide attenuates aeroallergen-induced inflammation in mice.
Jeffrey T. Chapman,Jeffrey T. Chapman,Jeffrey T. Chapman,Leo E. Otterbein,Leo E. Otterbein,Leo E. Otterbein,Jack A. Elias,Jack A. Elias,Augustine M.K. Choi,Augustine M.K. Choi,Augustine M.K. Choi +10 more
TL;DR: The data suggest a putative immunoregulatory role for CO in aeroallergen-induced inflammation in mice, and suggest that asthma is an inflammatory disease associated with increased oxidants and that CO confers cytoprotection in oxidant-induced lung injury and inflammation.