Jennifer E. Van Eyk

TL;DR: In this article, the authors characterized the TCR repertoire of multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory syndrome associated with SARS-CoV-2 infection, and found a profound expansion of TCRβ variable gene 11-2, with up to 24% of clonal T cell space occupied by TRBV11-2 T cells, which correlated with MIS-C severity and serum cytokine levels.

TL;DR: Day-of-injury serum BDNF is associated with TBI diagnosis and also provides 6-month prognostic information regarding recovery from TBI, and may aid in TBI risk stratification.

TL;DR: It is demonstrated that the PKCβ inhibitor enzastaurin, and the clinically available anti-hypertensive agent hydralazine, both normalize aortic growth in Marfan mice, in association with reduced PKC β and ERK1/2 activation.

TL;DR: The robustness and reproducibility of the optimized procedure was determined for three individual serum samples on three consecutive days, and an image analysis of the nine silver‐stained gels demonstrated that the intensity and localization of protein spots are highly reproducible.

TL;DR: The data indicate an essential role for Abl kinase in vascular barrier regulation via phosphorylation of nmMLCK and the actin-binding protein cortactin.