K
Kamini Kunasegaran
Researcher at National University of Singapore
Publications - 24
Citations - 3349
Kamini Kunasegaran is an academic researcher from National University of Singapore. The author has contributed to research in topics: T cell & Antibody. The author has an hindex of 11, co-authored 22 publications receiving 1580 citations.
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Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
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Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Anthony T. Tan,Martin Linster,Chee Wah Tan,Nina Le Bert,Wan Ni Chia,Kamini Kunasegaran,Yan Zhuang,Christine Y.L. Tham,Adeline Chia,Gavin J. D. Smith,Barnaby Edward Young,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,David C. Lye,Lin-Fa Wang,Antonio Bertoletti,Antonio Bertoletti +18 more
TL;DR: In this article, the authors quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T-cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins.
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Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.
Wan Ni Chia,Feng Zhu,Sean Wei Xiang Ong,Barnaby Edward Young,Barnaby Edward Young,Siew-Wai Fong,Nina Le Bert,Chee Wah Tan,Charles Tiu,Jinyan Zhang,Seow Yen Tan,Surinder Pada,Yi Hao Chan,Christine Y.L. Tham,Kamini Kunasegaran,Mark I-Cheng Chen,Jenny G. Low,Jenny G. Low,Yee Sin Leo,Laurent Rénia,Antonio Bertoletti,Lisa F. P. Ng,David C. Lye,Lin-Fa Wang +23 more
TL;DR: In this paper, the authors investigated the peak levels and dynamics of neutralising antibody waning and IgG avidity maturation over time, and correlate this with clinical parameters, cytokines, and T-cell responses.
Journal ArticleDOI
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.
Nina Le Bert,Hannah E. Clapham,Anthony T. Tan,Wan Ni Chia,Christine Y.L. Tham,Jane Mingjie Lim,Kamini Kunasegaran,Linda Wei Lin Tan,Charles-Antoine Dutertre,Nivedita Shankar,Joey M.E. Lim,Louisa Jin Sun,Marina Zahari,Zaw Myo Tun,Vishakha Kumar,Beng Lee Lim,Siew Hoon Lim,Adeline Chia,Yee-Joo Tan,Yee-Joo Tan,Paul A. Tambyah,Shirin Kalimuddin,Shirin Kalimuddin,David C. Lye,Jenny G. Low,Jenny G. Low,Lin-Fa Wang,Wei Yee Wan,Li Yang Hsu,Antonio Bertoletti,Antonio Bertoletti,Clarence C. Tam,Clarence C. Tam +32 more
TL;DR: In this article, SARS-CoV-2-specific T cells in a cohort of asymptomatic and symptomatic COVID-19 patients after seroconversion were longitudinally studied.
Journal ArticleDOI
Hepatitis B virus–specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation
Laura Rivino,Nina Le Bert,Nina Le Bert,Upkar S. Gill,Upkar S. Gill,Kamini Kunasegaran,Yang Cheng,D. Tan,Etienne Becht,N. Hansi,Graham R. Foster,Tung-Hung Su,Tai-Chung Tseng,Seng Gee Lim,Jia-Horng Kao,Evan W. Newell,Patrick T F Kennedy,Antonio Bertoletti,Antonio Bertoletti,Antonio Bertoletti +19 more
TL;DR: This study identifies the presence of functional HBV-specific T cells as a candidate immunological biomarker for safe therapy discontinuation in chronic HBV patients and highlights the potential beneficial role of the expression of T cell exhaustion markers during human chronic viral infection.