C
Chee Wah Tan
Researcher at National University of Singapore
Publications - 52
Citations - 3921
Chee Wah Tan is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 26 publications receiving 1846 citations. Previous affiliations of Chee Wah Tan include Agency for Science, Technology and Research.
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Journal ArticleDOI
A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction.
Chee Wah Tan,Wan Ni Chia,Xijian Qin,Pei Liu,Mark I-Cheng Chen,Charles Tiu,Zhiliang Hu,Zhiliang Hu,Vivian Chih Wei Chen,Barnaby Edward Young,Barnaby Edward Young,Wan Rong Sia,Yee-Joo Tan,Yee-Joo Tan,Randy Foo,Yongxiang Yi,David C. Lye,Danielle E. Anderson,Lin-Fa Wang +18 more
TL;DR: A blocking assay based on the recombinant receptor-binding domain of SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 receptor provides an alternative to conventional antibody neutralization assays requiring live virus.
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Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Anthony T. Tan,Martin Linster,Chee Wah Tan,Nina Le Bert,Wan Ni Chia,Kamini Kunasegaran,Yan Zhuang,Christine Y.L. Tham,Adeline Chia,Gavin J. D. Smith,Barnaby Edward Young,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,David C. Lye,Lin-Fa Wang,Antonio Bertoletti,Antonio Bertoletti +18 more
TL;DR: In this article, the authors quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T-cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins.
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Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.
Wan Ni Chia,Feng Zhu,Sean Wei Xiang Ong,Barnaby Edward Young,Barnaby Edward Young,Siew-Wai Fong,Nina Le Bert,Chee Wah Tan,Charles Tiu,Jinyan Zhang,Seow Yen Tan,Surinder Pada,Yi Hao Chan,Christine Y.L. Tham,Kamini Kunasegaran,Mark I-Cheng Chen,Jenny G. Low,Jenny G. Low,Yee Sin Leo,Laurent Rénia,Antonio Bertoletti,Lisa F. P. Ng,David C. Lye,Lin-Fa Wang +23 more
TL;DR: In this paper, the authors investigated the peak levels and dynamics of neutralising antibody waning and IgG avidity maturation over time, and correlate this with clinical parameters, cytokines, and T-cell responses.
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Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia.
Supaporn Wacharapluesadee,Chee Wah Tan,Patarapol Maneeorn,Prateep Duengkae,Feng Zhu,Yutthana Joyjinda,Thongchai Kaewpom,Wan Ni Chia,Weenassarin Ampoot,Beng Lee Lim,Kanthita Worachotsueptrakun,Vivian Chih Wei Chen,Nutthinee Sirichan,Chanida Ruchisrisarod,Apaporn Rodpan,Kirana Noradechanon,Thanawadee Phaichana,Niran Jantarat,Boonchu Thongnumchaima,Changchun Tu,Gary Crameri,Martha M. Stokes,Thiravat Hemachudha,Lin-Fa Wang +23 more
TL;DR: In this article, molecular and serological evidence of SARS-CoV-2 related coronaviruses (SC2r-CoVs) actively circulating in bats in Southeast Asia was reported.
Journal ArticleDOI
Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2.
Yvonne C. F. Su,Danielle E. Anderson,Barnaby Edward Young,Martin Linster,Feng Zhu,Jayanthi Jayakumar,Yan Zhuang,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,Chee Wah Tan,Wan Ni Chia,Tze Minn Mak,Sophie Octavia,Jean-Marc Chavatte,Raphael T.C. Lee,Surinder Pada,Seow Yen Tan,Louisa Sun,Gabriel Yan,Sebastian Maurer-Stroh,Sebastian Maurer-Stroh,Ian H. Mendenhall,Yee Sin Leo,David C. Lye,Lin-Fa Wang,Lin-Fa Wang,Gavin J. D. Smith,Gavin J. D. Smith +29 more
TL;DR: A robust antibody response to ORF8 has been observed in SARS-CoV-2 infection, suggesting that the emergence of ORF7b/8 deletions may be due to immune-driven selection and that further deletion variants may emerge during the sustained transmission of Sars-Cov-2 in humans.