J
Jenny Y. Y. Ooi
Researcher at Baker IDI Heart and Diabetes Institute
Publications - 23
Citations - 1656
Jenny Y. Y. Ooi is an academic researcher from Baker IDI Heart and Diabetes Institute. The author has contributed to research in topics: Heart failure & Cardiac function curve. The author has an hindex of 15, co-authored 21 publications receiving 1251 citations. Previous affiliations of Jenny Y. Y. Ooi include Monash University, Clayton campus.
Papers
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Journal ArticleDOI
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets.
Yow Keat Tham,Yow Keat Tham,Bianca C. Bernardo,Jenny Y. Y. Ooi,Kate L. Weeks,Julie R. McMullen,Julie R. McMullen +6 more
TL;DR: New therapeutic approaches either entering clinical trials or in preclinical development, and the challenges that remain in translating these discoveries to new and approved therapies for heart failure are addressed.
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Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling.
Julie R. McMullen,Esther J. H. Boey,Jenny Y. Y. Ooi,John F. Seymour,John F. Seymour,Michael J. Keating,Constantine S. Tam,Constantine S. Tam +7 more
TL;DR: Ibrutinib is generally well tolerated and largely well tolerated in patients with relapsed or refractory chronic lymphocytic leukemia and mantle cell lymphoma.
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miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart
TL;DR: The authors describe the contribution of miRNAs to cardiac biology and disease and discuss various strategies for manipulating miRNA activity including antisense oligonucleotides, mimics, miRNA sponges, Tough Decoys and miRNA mowers.
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The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice
Geeta Sapra,Yow Keat Tham,Nelly Cemerlang,Aya Matsumoto,Helen Kiriazis,Bianca C. Bernardo,Darren C. Henstridge,Jenny Y. Y. Ooi,Lynette Pretorius,Esther J. H. Boey,Lydia Lim,Junichi Sadoshima,Peter J. Meikle,Natalie A. Mellet,Elizabeth A. Woodcock,Silvana Marasco,Tomomi Ueyama,Xiao-Jun Du,Mark A. Febbraio,Julie R. McMullen +19 more
TL;DR: It is demonstrated that BGP-15 and IGF1R can provide protection independent of phosphoinositide 3-kinase-Akt and heat-shock protein 70; signalling mediators often defective in the aged and diseased heart.
Journal ArticleDOI
HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes
Jenny Y. Y. Ooi,Natasha K. Tuano,Haloom Rafehi,Xiao-Ming Gao,Mark Ziemann,Xiao-Jun Du,Assam El-Osta +6 more
TL;DR: A framework for HDAC inhibitor function in the heart is provided and the long held views of acetylation is subject to more flexibility than previously thought are argued.