J
Jeong Wook Lee
Researcher at Pohang University of Science and Technology
Publications - 70
Citations - 6841
Jeong Wook Lee is an academic researcher from Pohang University of Science and Technology. The author has contributed to research in topics: Succinic acid & Escherichia coli. The author has an hindex of 25, co-authored 69 publications receiving 5072 citations. Previous affiliations of Jeong Wook Lee include Wyss Institute for Biologically Inspired Engineering & Boston University.
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Journal ArticleDOI
Nucleic acid detection with CRISPR-Cas13a/C2c2
Jonathan S. Gootenberg,Omar O. Abudayyeh,Jeong Wook Lee,Patrick Essletzbichler,Aaron J. Dy,Aaron J. Dy,Julia Joung,Vanessa Verdine,Nina M. Donghia,Nichole M. Daringer,Catherine A. Freije,Catherine A. Freije,Cameron Myhrvold,Cameron Myhrvold,Roby P. Bhattacharyya,Jonathan Livny,Aviv Regev,Aviv Regev,Eugene V. Koonin,Deborah T. Hung,Pardis C. Sabeti,James J. Collins,Feng Zhang +22 more
TL;DR: A Cas13a-based molecular detection platform, termed Specific High-Sensitivity Enzymatic Reporter UnLOCKing (SHERLOCK), is used to detect specific strains of Zika and Dengue virus, distinguish pathogenic bacteria, genotype human DNA, and identify mutations in cell-free tumor DNA.
Journal ArticleDOI
Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components
Keith Pardee,Alexander A. Green,Melissa K. Takahashi,Dana Braff,Dana Braff,Dana Braff,Guillaume Lambert,Guillaume Lambert,Jeong Wook Lee,Tom Ferrante,Duo Ma,Nina M. Donghia,Melina Fan,Nichole M. Daringer,Irene Bosch,Dawn M. Dudley,David H. O’Connor,Lee Gehrke,Lee Gehrke,James J. Collins +19 more
TL;DR: A pipeline for the rapid design, assembly, and validation of cell-free, paper-based sensors for the detection of the Zika virus RNA genome is reported, which detect clinically relevant concentrations of Zika virus sequences and demonstrate specificity against closely related Dengue virus sequences.
Nucleic acid detection with CRISPR-Cas13a/C2c2
Jonathan S. Gootenberg,Omar O. Abudayyeh,Jeong Wook Lee,Patrick Essletzbichler,Aaron J. Dy,Aaron J. Dy,Julia Joung,Vanessa Verdine,Nina M. Donghia,Nichole M. Daringer,Catherine A. Freije,Catherine A. Freije,Cameron Myhrvold,Cameron Myhrvold,Roby P. Bhattacharyya,Jonathan Livny,Aviv Regev,Aviv Regev,Eugene V. Koonin,Deborah T. Hung,Pardis C. Sabeti,James J. Collins,Feng Zhang +22 more
TL;DR: In this paper, a CRISPR-Dx-based molecular detection platform, termed Specific High-Sensitivity Enzymatic Reporter Unlocking (SHERLOCK), was proposed to detect specific strains of Zika and Dengue virus, distinguish pathogenic bacteria, genotype human DNA, and identify mutations in cell-free tumor DNA.
Journal ArticleDOI
Systems metabolic engineering of microorganisms for natural and non-natural chemicals
TL;DR: The general strategies of systems metabolic engineering are discussed and examples of its application are offered and insights are offered as to when and how each of the different strategies should be used.
Journal ArticleDOI
Portable, On-Demand Biomolecular Manufacturing
Keith Pardee,Shimyn Slomovic,Peter Q. Nguyen,Jeong Wook Lee,Jeong Wook Lee,Nina M. Donghia,Devin R. Burrill,Tom Ferrante,Fern R. McSorley,Yoshikazu Furuta,Andyna Vernet,Michael P. Lewandowski,Christopher N. Boddy,Neel Joshi,Neel Joshi,James J. Collins +15 more
TL;DR: This paper presents a portable platform that provides the means for on-site, on-demand manufacturing of therapeutics and biomolecules and demonstrates the manufacture and functional validation of antimicrobial peptides and vaccines and presents combinatorial methods for the production of antibody conjugates and small molecules.