T
Tom Ferrante
Researcher at Wyss Institute for Biologically Inspired Engineering
Publications - 4
Citations - 1386
Tom Ferrante is an academic researcher from Wyss Institute for Biologically Inspired Engineering. The author has contributed to research in topics: Phosphorylation & Synthetic biology. The author has an hindex of 4, co-authored 4 publications receiving 980 citations.
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Journal ArticleDOI
Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components
Keith Pardee,Alexander A. Green,Melissa K. Takahashi,Dana Braff,Dana Braff,Dana Braff,Guillaume Lambert,Guillaume Lambert,Jeong Wook Lee,Tom Ferrante,Duo Ma,Nina M. Donghia,Melina Fan,Nichole M. Daringer,Irene Bosch,Dawn M. Dudley,David H. O’Connor,Lee Gehrke,Lee Gehrke,James J. Collins +19 more
TL;DR: A pipeline for the rapid design, assembly, and validation of cell-free, paper-based sensors for the detection of the Zika virus RNA genome is reported, which detect clinically relevant concentrations of Zika virus sequences and demonstrate specificity against closely related Dengue virus sequences.
Journal ArticleDOI
Portable, On-Demand Biomolecular Manufacturing
Keith Pardee,Shimyn Slomovic,Peter Q. Nguyen,Jeong Wook Lee,Jeong Wook Lee,Nina M. Donghia,Devin R. Burrill,Tom Ferrante,Fern R. McSorley,Yoshikazu Furuta,Andyna Vernet,Michael P. Lewandowski,Christopher N. Boddy,Neel Joshi,Neel Joshi,James J. Collins +15 more
TL;DR: This paper presents a portable platform that provides the means for on-site, on-demand manufacturing of therapeutics and biomolecules and demonstrates the manufacture and functional validation of antimicrobial peptides and vaccines and presents combinatorial methods for the production of antibody conjugates and small molecules.
Journal ArticleDOI
BioBits™ Explorer: A modular synthetic biology education kit.
Ally Huang,Ally Huang,Peter Q. Nguyen,Peter Q. Nguyen,Jessica C. Stark,Melissa K. Takahashi,Nina M. Donghia,Tom Ferrante,Aaron J. Dy,Karen J. Hsu,Rachel S. Dubner,Keith Pardee,Michael C. Jewett,James J. Collins +13 more
TL;DR: The BioBits™ Explorer kit enables hands-on demonstrations of cutting-edge science that are inexpensive and easy to use, circumventing many current barriers for implementing exploratory biology experiments in classrooms.
Journal ArticleDOI
Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.
Di Feng,Di Feng,Mukesh Kumar,Jan Muntel,Susan B. Gurley,Gabriel Birrane,Isaac E. Stillman,Lai Ding,Minxian Wang,Saima Ahmed,Johannes Schlondorff,Seth L. Alper,Seth L. Alper,Tom Ferrante,Susan Marquez,Carlos F. Ng,Richard M. Novak,Donald E. Ingber,Hanno Steen,Martin R. Pollak,Martin R. Pollak +20 more
TL;DR: It is suggested that increased phosphorylation of ACTN4 at S159 leads to biochemical, cellular, and renal pathology that is similar to pathology resulting from human disease-causing mutations in ACTn4.