J
Jeroen Buters
Researcher at Technische Universität München
Publications - 153
Citations - 7708
Jeroen Buters is an academic researcher from Technische Universität München. The author has contributed to research in topics: Pollen & Aerobiology. The author has an hindex of 45, co-authored 137 publications receiving 6722 citations. Previous affiliations of Jeroen Buters include National Institutes of Health & University of Bern.
Papers
More filters
Journal ArticleDOI
Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization
Paraskevi Giannakakou,Dan L. Sackett,Yoon-Koo Kang,Zhirong Zhan,Jeroen Buters,Tito Fojo,Marianne S. Poruchynsky +6 more
TL;DR: Results identify residues β270 and β364 as important modulators of paclitaxel’s interaction with tubulin as well as acquired mutations in the M40 isotype at nucleotide 810 (T → G; Phe270 → Val) in 1A9PTX10 cells and nucleotide 1092 (G → A; Ala364 → Thr) in1A 9PTX22 cells.
Journal ArticleDOI
Role of CYP2E1 in the Hepatotoxicity of Acetaminophen
TL;DR: When cyp2e1 knockout mice were challenged with the common analgesic acetaminophen, they were found to be considerably less sensitive to its hepatotoxic effects than wild-type animals, indicating that this P-450 is the principal enzyme responsible for the metabolic conversion of the drug to its active hepatot toxic metabolite.
Journal ArticleDOI
Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas
Jeroen Buters,Shuichi Sakai,Thomas Richter,Thierry Pineau,David L. Alexander,Uzen Savas,Johannes Doehmer,Jerrold M. Ward,Colin R. Jefcoate,Frank J. Gonzalez +9 more
TL;DR: CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype as discussed by the authors.
Journal ArticleDOI
Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization
Gennaro D'Amato,Stephen T. Holgate,Ruby Pawankar,Dennis K. Ledford,Lorenzo Cecchi,Mona Al-Ahmad,Fatma Al-Enezi,Saleh Al-Muhsen,Ignacio J. Ansotegui,Carlos E. Baena-Cagnani,David J. Baker,Hasan Bayram,Karl Christian Bergmann,Louis-Philippe Boulet,Jeroen Buters,Maria D'Amato,Sofia Dorsano,Jeroen Douwes,Sarah Elise Finlay,Donata Garrasi,Maximiliano Gómez,Tari Haahtela,Rabih Halwani,Youssouf Hassani,Basam Mahboub,Guy B. Marks,Paola Michelozzi,Marcello Montagni,Carlos Nunes,Jay Jae-Won Oh,Todor A. Popov,Jay M. Portnoy,Erminia Ridolo,Nelson Rosario,Menachem Rottem,Mario Sánchez-Borges,Elopy Sibanda,Juan José Sienra-Monge,Carolina Vitale,Isabella Annesi-Maesano +39 more
TL;DR: Global warming is expected to affect the start, duration, and intensity of the pollen season, and the rate of asthma exacerbations due to air pollution, respiratory infections, and/or cold air inhalation, and other conditions on the other hand.
Journal ArticleDOI
Protection against Acetaminophen Toxicity in CYP1A2 and CYP2E1 Double-Null Mice ☆
Hani Zaher,Jeroen Buters,Jerrold M. Ward,Mary K. Bruno,Angela M. Lucas,Stephan T. Stern,Steven D. Cohen,Frank J. Gonzalez +7 more
TL;DR: The protection against APAP toxicity afforded by deletion of both CYP2E1 and CYP1A2 likely reflects greatly diminished production of the toxic electrophile, NAPQI.