J
Jeroen Korving
Researcher at Utrecht University
Publications - 26
Citations - 9452
Jeroen Korving is an academic researcher from Utrecht University. The author has contributed to research in topics: Stem cell & LGR5. The author has an hindex of 20, co-authored 23 publications receiving 8108 citations. Previous affiliations of Jeroen Korving include Royal Netherlands Academy of Arts and Sciences & Fundamental Research on Matter Institute for Atomic and Molecular Physics.
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Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.
Journal ArticleDOI
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
Nick Barker,Meritxell Huch,Pekka Kujala,Marc van de Wetering,Hugo J. Snippert,Johan H. van Es,Toshiro Sato,Daniel E. Stange,Harry Begthel,Maaike van den Born,Esther Danenberg,Stieneke van den Brink,Jeroen Korving,Arie Abo,Peter J. Peters,Peter J. Peters,Nicholas A. Wright,Richard Poulsom,Hans Clevers +18 more
TL;DR: The Lgr5 stem cell marker and culture method described here will be invaluable tools for accelerating research into gastric epithelial renewal, inflammation/infection, and cancer.
Journal ArticleDOI
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
Johan H. van Es,Toshiro Sato,Marc van de Wetering,Anna Lyubimova,Annie Ng Yee Nee,Alex Gregorieff,Nobuo Sasaki,Laura Zeinstra,Maaike van den Born,Jeroen Korving,Anton C.M. Martens,Nick Barker,Alexander van Oudenaarden,Hans Clevers +13 more
TL;DR: Lineage tracing in Dll1GFP–ires–CreERT2 knock-in mice reveals that single Dll 1high cells generate small, short-lived clones containing all four secretory cell types, which exhibit plasticity by regaining stemness on damage.
Journal ArticleDOI
Long-term expanding human airway organoids for disease modeling
Norman Sachs,Angelos Papaspyropoulos,Domenique D. Zomer-van Ommen,Inha Heo,Lena Böttinger,Dymph Klay,Fleur Weeber,Guizela Huelsz-Prince,Nino Iakobachvili,Gimano D. Amatngalim,Joep de Ligt,Arne Van Hoeck,Natalie Proost,Marco C. Viveen,Anna Lyubimova,Luc Teeven,Sepideh Derakhshan,Jeroen Korving,Harry Begthel,Johanna F. Dekkers,Kuldeep Kumawat,Emilio Ramos,Matthijs F.M. van Oosterhout,G. Johan A. Offerhaus,Dominique J Wiener,Eduardo P. Olimpio,Krijn K. Dijkstra,Egbert F. Smit,Maarten van der Linden,Sridevi Jaksani,Marieke van de Ven,Jos Jonkers,Anne C. Rios,Emile E. Voest,Coline H.M. van Moorsel,Cornelis K. van der Ent,Edwin Cuppen,Alexander van Oudenaarden,Frank E. J. Coenjaerts,Linde Meyaard,Louis Bont,Peter J. Peters,Sander J. Tans,Jeroen S. van Zon,Sylvia F. Boj,Robert G.J. Vries,Jeffrey M. Beekman,Hans Clevers +47 more
TL;DR: It is concluded that human airway organoids represent versatile models for the in vitro study of hereditary, malignant, and infectious pulmonary disease.
Journal ArticleDOI
The Wnt/beta-catenin pathway regulates cardiac valve formation.
Adam Hurlstone,Anna-Pavlina G. Haramis,Erno Wienholds,Harry Begthel,Jeroen Korving,Fredericus J.M. van Eeden,Edwin Cuppen,Danica Zivkovic,Ronald H.A. Plasterk,Hans Clevers +9 more
TL;DR: A novel role is identified for Wnt/β-catenin signalling in determining endocardial cell fate in zebrafish development and, in contrast to mice, zebra fish do complete gastrulation.