Jianbo Wu

TL;DR: In this paper, a convalescent individual with potent IgG neutralizing activity and characterize his antibody response was selected, and the relationship between enhancing versus neutralizing activities and antibody epitopes remains unknown.

TL;DR: The co-crystal structure of one of the bNAbs with an HBsAg peptide epitope revealed a stabilized hairpin loop, which contains residues frequently mutated in clinical immune escape variants, provides a molecular explanation for why immunotherapy for HBV infection may require combinations of complementary bNABS.

TL;DR: In this article, the authors dissected the immunogenic profiles of antibodies from 3-dose vaccine, 2-dose and convalescents and found that a third booster dose of inactivated vaccine produces a highly sifted humoral immune response via a sustained evolution of antibodies capable of effectively neutralizing SARS-CoV-2 variants of concern.

TL;DR: This article identified a receptor-binding domain (RBD)-binding antibody, XG014, which potently neutralizes β-coronavirus lineage B (β-CoV-B), including SARS-Cov-2, its circulating variants, SARS CoV and bat SARSr CoV WIV1.

TL;DR: Omicron, with a dramatically increased infectivity and enhanced transmissibility, is rapidly replacing the Delta variant and is poised to become a predominately prevalent strain in more than 110 countries since it was reported in South Africa at the end of 2021.