P
Pin Li
Researcher at Genome Institute of Singapore
Publications - 10
Citations - 1733
Pin Li is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 9, co-authored 10 publications receiving 1642 citations. Previous affiliations of Pin Li include Agency for Science, Technology and Research.
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Journal ArticleDOI
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
Joon-Lin Chew,Yuin-Han Loh,Yuin-Han Loh,Wensheng Zhang,Xi Chen,Xi Chen,Wai Leong Tam,Leng-Siew Yeap,Pin Li,Yen-Sin Ang,Bing Lim,Bing Lim,Paul Robson,Paul Robson,Huck-Hui Ng,Huck-Hui Ng +15 more
TL;DR: A positive and potentially self-reinforcing regulatory loop that maintains Pou5f1 and Sox2 expression via the Oct4/Sox2 complex in pluripotent cells is uncovered.
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A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
Na-Yu Chia,Yun-Shen Chan,Yun-Shen Chan,Bo Feng,Xinyi Lu,Xinyi Lu,Yuriy L. Orlov,Dimitri Moreau,Pankaj Kumar,Lin Yang,Jianming Jiang,Mei-Sheng Lau,Mikael Huss,Boon Seng Soh,Petra Kraus,Pin Li,Thomas Lufkin,Bing Lim,Bing Lim,Neil D. Clarke,Neil D. Clarke,Frederic Bard,Frederic Bard,Huck-Hui Ng +23 more
TL;DR: A genome-wide RNA interference screen to identify genes which regulate self-renewal and pluripotency properties in hESCs uncovers a wealth of novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of h ESC identity and the reacquisition of pluripOTency in human somatic cells.
Journal ArticleDOI
Tbx3 improves the germ-line competency of induced pluripotent stem cells
Jianyong Han,Ping Yuan,Henry Yang,Jinqiu Zhang,Boon Seng Soh,Pin Li,Siew Lan Lim,Suying Cao,Junliang Tay,Yuriy L. Orlov,Thomas Lufkin,Huck-Hui Ng,Wai Leong Tam,Bing Lim +13 more
TL;DR: iPS cells generated with OSK and Tbx3 (OSKT) are superior in both germ-cell contribution to the gonads and germ-line transmission frequency, and the need to rigorously characterize iPS cells beyond in vitro studies is highlighted.
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Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures.
Tong Cao,Boon Chin Heng,Chao Peng Ye,Hua Liu,Wei Seong Toh,Paul Robson,Pin Li,Yun Han Hong,Lawrence W. Stanton +8 more
TL;DR: After 22 days of culture in osteogenesis-promoting medium comprising a cocktail of ascorbic acid, beta-glycerophosphate and dexamethasone, the attached embryoid bodies exhibited much cellular outgrowth and migration, and formed morphologically distinct nodule-like structures, similar to osteogenic nodules formed by mesenchymal stem cells.
Journal ArticleDOI
Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells.
Zheng‐Xu Wang,Jacqueline L.L. Kueh,Christina Hui‐Leng Teh,Michael Rossbach,Linda Lim,Pin Li,Kee-Yew Wong,Thomas Lufkin,Thomas Lufkin,Paul Robson,Paul Robson,Lawrence W. Stanton,Lawrence W. Stanton +12 more
TL;DR: The results show that Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells.