J
Jiaxiong Wang
Researcher at Nanjing Medical University
Publications - 22
Citations - 491
Jiaxiong Wang is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Male infertility & Sperm. The author has an hindex of 5, co-authored 14 publications receiving 275 citations.
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Journal ArticleDOI
Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella
Shuyan Tang,Xiong Wang,Xiong Wang,Weiyu Li,Xiaoyu Yang,Zheng Li,Wangjie Liu,Caihua Li,Zi-Jue Zhu,Lingxiang Wang,Jiaxiong Wang,Ling Zhang,Xiaoling Sun,Erlei Zhi,Hongyan Wang,Hong Li,Li Jin,Yang Luo,Jian Wang,Shenmin Yang,Feng Zhang +20 more
TL;DR: The authors' experimental observations on human subjects and animal models strongly suggest that biallelic mutations in either CFAP43 or CFAP44 can cause sperm flagellar abnormalities and impair sperm motility.
Journal ArticleDOI
Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice.
Wangjie Liu,Xiaojin He,Shenmin Yang,Raoudha Zouari,Jiaxiong Wang,Huan Wu,Zine Eddine Kherraf,Chunyu Liu,Chunyu Liu,Charles Coutton,Rui Zhao,Dongdong Tang,Shuyan Tang,Mingrong Lv,Youyan Fang,Weiyu Li,Weiyu Li,Hong Li,Jian-Yuan Zhao,Xue Wang,Shimin Zhao,Jingjing Zhang,Christophe Arnoult,Li Jin,Zhiguo Zhang,Pierre F. Ray,Pierre F. Ray,Yunxia Cao,Feng Zhang +28 more
TL;DR: Wang et al. as discussed by the authors used whole-exome sequencing in a cohort of 65 Han Chinese men with MMAF and revealed sperm structural defects of the flagella and the connecting piece.
Journal ArticleDOI
Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility
Chunyu Liu,Chaofeng Tu,Lingbo Wang,Huan Wu,Brendan J Houston,Francesco K. Mastrorosa,Wen Zhang,Ying Shen,Jiaxiong Wang,Shixiong Tian,Lanlan Meng,Jiangshan Cong,Shenmin Yang,Yiwen Jiang,Shuyan Tang,Yuyan Zeng,Mingrong Lv,Mingrong Lv,Ge Lin,Jinsong Li,Hexige Saiyin,Xiaojin He,Xiaojin He,Li Jin,Aminata Touré,Pierre F. Ray,Joris A. Veltman,Qinghua Shi,Moira K O'Bryan,Moira K O'Bryan,Yunxia Cao,Yunxia Cao,Yue-Qiu Tan,Feng Zhang +33 more
TL;DR: Wang et al. as mentioned in this paper conducted whole-exome sequencing (WES) and identified hemizygous missense variants in the X-linked CFAP47 in three unrelated Chinese individuals with MMAF.
Journal ArticleDOI
Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice.
Chunyu Liu,Xiaojin He,Wangjie Liu,Wangjie Liu,Shenmin Yang,Lingbo Wang,Weiyu Li,Weiyu Li,Huan Wu,Shuyan Tang,Xiaoqing Ni,Jiaxiong Wang,Yang Gao,Shixiong Tian,Shixiong Tian,Lin Zhang,Jiangshan Cong,Z. Zhang,Qing Tan,Jingjing Zhang,Hong Li,Yading Zhong,Mingrong Lv,Jinsong Li,Li Jin,Yunxia Cao,Feng Zhang,Feng Zhang +27 more
TL;DR: Bi-allelic mutations in TTC29, as an important genetic pathogeny, can induce MMAF-related asthenoteratospermia and provide effective guidance for clinical diagnosis and assisted reproduction treatments.
Journal ArticleDOI
Morphological characteristics and initial genetic study of multiple morphological anomalies of the flagella in China.
Shen-Min Yang,Haibo Li,Jiaxiong Wang,Yi-Chao Shi,Hong-Bo Cheng,Wei Wang,Hong Li,Jian-Quan Hou,Duan-gai Wen +8 more
TL;DR: It has been demonstrated that absolute asthenozoospermia in MMAF is not secondary to necrospermia, and the flagellar anomalies showed typical MMAF anomalies, with short, thick and irregular tails.