J
Jie Zheng
Researcher at University of Bristol
Publications - 127
Citations - 9389
Jie Zheng is an academic researcher from University of Bristol. The author has contributed to research in topics: Mendelian randomization & Medicine. The author has an hindex of 22, co-authored 76 publications receiving 4852 citations. Previous affiliations of Jie Zheng include Medical Research Council.
Papers
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Journal ArticleDOI
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity
Jie Zheng,Yue-miao Zhang,Huiling Zhao,Yi Liu,Denis Baird,Mohd Anisul Karim,Maya Ghoussaini,Jeremy Schwartzentruber,Ian Dunham,Benjamin Elsworth,Katherine Roberts,H. Compton,Felix Miller-Molloy,Xing-Zi Liu,Lin Wang,Hongke Zhang,Tom R. Gaunt +16 more
TL;DR: In this article , Mendelian randomization (MR) and colocalization approaches were applied to understand the putative causal effects of 16,059 transcripts and 1608 proteins on COVID-19 severity in European and effects of 610 proteins on CoVID-2019 severity in African ancestry.
Journal Article
MR-TRYX: Exploiting horizontal pleiotropy to infer novel causal pathways
Yoonsu Cho,Philip C Haycock,Tom R. Gaunt,Jie Zheng,Andrew P. Morris,Andrew P. Morris,George Davey Smith,Gibran Hemani +7 more
TL;DR: In this paper, a LASSO-based multivariable Mendelian randomization (MR-TRYX) approach was developed to model the heterogeneity in the exposure-outcome analysis due to pathways through candidate traits.
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Mendelian Randomization Analysis Reveals a Causal Effect of Urinary Sodium/Urinary Creatinine Ratio on Kidney Function in Europeans
TL;DR: Evidence is provided that sodium excretion, well above the recommendation of <2 g per day of sodium intake, might not have a harmful effect on kidney function, and clinical trials are warranted to evaluate the sodium restriction target on kidneys function.
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The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study
Maria Carolina Borges,Philip C Haycock,Jie Zheng,Gibran Hemani,Laurence J. Howe,Amand F. Schmidt,James R Staley,R. Thomas Lumbers,Albert Henry,Rozenn N. Lemaitre,Tom R. Gaunt,Michael C. Holmes,George Davey-Smith,Aroon D. Hingorani,D. A. Lawlor +14 more
TL;DR: The findings indicate that genetically-determined PUFA and MUFA biosynthesis are involved in the aetiology of cardiovascular diseases and suggest LDL-cholesterol as a potential mediating trait between PUFA biosynthetic rate and cardiovascular diseases risk.
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Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization
T. Hou,Huajie Dai,Qi Wang,Yanan Hou,Xiaoyun Zhang,Hong Lin,Shuangyuan Wang,Mian Li,Zhiyun Zhao,Jieli Lu,Yu Xu,Yu-Hong Chen,Yanyun Gu,Jie Zheng,Tian Wang,Weiqing Wang,Yufang Bi,Guang Ning,Min Xu +18 more
TL;DR: In this paper , the interactive causal effects between gut microbiota and host urate metabolism and explore the underlying mechanism using genetic methods were investigated using linkage disequilibrium score regression and bidirectional Mendelian randomization.