J
Jie Zheng
Researcher at University of Bristol
Publications - 127
Citations - 9389
Jie Zheng is an academic researcher from University of Bristol. The author has contributed to research in topics: Mendelian randomization & Medicine. The author has an hindex of 22, co-authored 76 publications receiving 4852 citations. Previous affiliations of Jie Zheng include Medical Research Council.
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Journal ArticleDOI
GWAS META-analysis followed by MENDELIAN randomisation revealed potential control mechanisms for circulating α-klotho levels.
Ingrid Gergei,Ingrid Gergei,Jie Zheng,Till F. M. Andlauer,Till F. M. Andlauer,Vincent Brandenburg,Nazanin Mirza-Schreiber,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Bernhard K. Krämer,Daniel Richard,Louise Falk,Sofia Movérare-Skrtic,Claes Ohlsson,Claes Ohlsson,George Davey Smith,Winfried März,Winfried März,Winfried März,Jakob Voelkl,Jakob Voelkl,Jonathan H Tobias,Jonathan H Tobias +22 more
TL;DR: In this article, a GWAS meta-analysis followed by Mendelian randomisation of circulating α-Klotho levels was conducted to investigate the role of B4GALNT3 and CHST9 enzymes in the influence of protein turnover and stability.
Journal ArticleDOI
Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses
Jie Chen,Fengzhe Xu,Xixian Ruan,Jing Sun,Yao-Chen Zhang,Han Zhang,Jianhui Zhao,Jie Zheng,Susanna C. Larsson,Xiao-Yang Wang,Xia Li,Shuai Yuan +11 more
TL;DR: In this paper , a proteome-wide Mendelian randomization (MR) and colocalization analyses were conducted to identify possible targets for inflammatory bowel disease (IBD) in a large-scale protein quantitative trait loci study.
Posted ContentDOI
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank
Ioanna Tachmazidou,Konstantinos Hatzikotoulas,Lorraine Southam,Lorraine Southam,Jorge Esparza-Gordillo,Valeriia Haberland,Jie Zheng,Toby Johnson,Mine Koprulu,Eleni Zengini,Julia Steinberg,Jeremy Mark Wilkinson,Sahir Bhatnagar,Joshua D. Hoffman,Natalie Buchan,Daniel Suveges,Laura M Yerges Armstrong,George Davey Smith,Tom R. Gaunt,Robert A. Scott,Linda McCarthy,Eleftheria Zeggini +21 more
TL;DR: This largest genome-wide association study for osteoarthritis to date, analysing 4 phenotypes, finds enrichment for genes underlying monogenic forms of bone development diseases, and for the collagen formation and extracellular matrix organisation biological pathways.
Posted ContentDOI
Best practices for multi-ancestry, meta-analytic transcriptome-wide association studies: lessons from the Global Biobank Meta-analysis Initiative
Arjun Bhattacharya,Jibril Hirbo,Jibril Hirbo,Dan Zhou,Dan Zhou,Wei Zhou,Wei Zhou,Jie Zheng,Masahiro Kanai,Mark J. Daly,Bogdan Pasaniuc,Bogdan Pasaniuc,Bogdan Pasaniuc,Eric R. Gamazon,Eric R. Gamazon,Eric R. Gamazon,Nancy J. Cox,Nancy J. Cox +17 more
TL;DR: The Global Biobank Meta-analysis Initiative (GBMI) provides a valuable opportunity to study population-wide and ancestry-specific genetic associations as mentioned in this paper, however, with multiple ascertainment strategies and multi-ethnic study populations across biobanks, the GBMI provides a distinct set of challenges in implementing statistical genetics methods.
Journal ArticleDOI
Causal effect of lower birthweight on non‐alcoholic fatty liver disease and mediating roles of insulin resistance and metabolites
L. Kong,C. Ye,Yi Ying Wang,Jie Zheng,Zhiyun Zhao,Mian Li,Yu Xu,Jieli Lu,Yu-Hong Chen,Min Xu,Weiqing Wang,Guang Ning,Yufang Bi,Tian Wang +13 more
TL;DR: In this article, the causal association of lower birthweight with non-alcoholic fatty liver disease (NAFLD) and mediating pathways was investigated and the causal, independent association was established.