J
Jie Zheng
Researcher at University of Bristol
Publications - 127
Citations - 9389
Jie Zheng is an academic researcher from University of Bristol. The author has contributed to research in topics: Mendelian randomization & Medicine. The author has an hindex of 22, co-authored 76 publications receiving 4852 citations. Previous affiliations of Jie Zheng include Medical Research Council.
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Journal ArticleDOI
Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
Huiling Zhao,Humaria Rasheed,Therese Haugdahl Nøst,Yoonsu Cho,Yi Liu,Laxmi Bhatta,Arjun Bhattacharya,Gibran Hemani,George Davey Smith,Ben Michael Brumpton,Wei Zhou,Benjamin M. Neale,Tom R. Gaunt,Jie Zheng +13 more
TL;DR: In this article , a multi-ancestry proteome-wide Mendelian randomization (MR) analysis based on cross-population data from the Global Biobank Meta-analysis Initiative (GBMI) is presented.
Journal ArticleDOI
HAPRAP: a haplotype-based iterative method for statistical fine mapping using GWAS summary statistics
Jie Zheng,Santiago Rodriguez,Charles Laurin,Denis Baird,Lea Trela-Larsen,A. Mesut Erzurumluoglu,A. Mesut Erzurumluoglu,Yi Zheng,Jon White,Claudia Giambartolomei,Delilah Zabaneh,Richard W Morris,Meena Kumari,Juan P. Casas,Aroon D. Hingorani,David M. Evans,Tom R. Gaunt,Ian N. M. Day +17 more
TL;DR: An empirical iterative method, HAPlotype Regional Association analysis Program (HAPRAP), that enables fine mapping using summary statistics and haplotype information from an individual-level reference panel and is demonstrated to be less sensitive to poor LD estimates.
Journal ArticleDOI
Collapsed Methylation Quantitative Trait Loci analysis for Low Frequency and Rare variants
Tom G. Richardson,Hashem A. Shihab,Gibran Hemani,Jie Zheng,Eilis Hannon,Jonathan Mill,Jonathan Mill,Elena Carnero-Montoro,Jordana T. Bell,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Santiago Rodriguez,Colin Campbell,George Davey Smith,Caroline L Relton,Nicholas J. Timpson,Tom R. Gaunt +17 more
TL;DR: The potential of this novel approach to mQTL analysis by analysing the combined effect of multiple low frequency or rare variants to identify regions of low frequency and rare variants associated with DNA methylation levels is demonstrated.
Journal ArticleDOI
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Ying Wang,Shinichi Namba,Esteban Parra Lopera,Sini Kerminen,Kristin Tsuo,Kristi Läll,Masahiro Kanai,Weihang Zhou,Kuan-Han Wu,Marie-Julie Favé,Laxmi Bhatta,Philip Awadalla,Ben Michael Brumpton,P.M. Van Deelen,Kristian Hveem,Valeria Lo Faro,Reedik Mägi,Yoshinori Murakami,Serena Sanna,Jordan W. Smoller,Jasmina Uzunović,Brooke N. Wolford,Cristen J. Willer,Eric R. Gamazon,Nancy J. Cox,Ida Surakka,Yukinori Okada,Kuan-Han H. Wu,Humaira Rasheed,Jibril Hirbo,Ying Wang,Arjun Bhattacharya,Huiling Zhao,E. A. Lopera-Maya,Sinéad B. Chapman,Juha Karjalainen,Mitja I. Kurki,Maasha Mutaamba,Juulia Partanen,Sameer Chavan,Michelle Daya,Yi Ding,Yen-Chen Anne Feng,Christopher R. Gignoux,Sarah E. Graham,Whitney E. Hornsby,Nathan Ingold,Ruth E. Johnson,Triin Laisk,Kuang Lin,Jun Lv,Iona Y. Millwood,Priit Palta,Anita Pandit,Michael Preuss,Unnur Thorsteinsdottir,Matthew Zawistowski,Xue Zhong,Archie Campbell,Kristy Crooks,Geertruida H. de Bock,Nicholas J. Douville,Sarah Finer,Lars G. Fritsche,Chris Griffiths,Yu Guo,Karen A. Hunt,Takahiro Konuma,Riccardo E. Marioni,Jansonius Nomdo,Snehal Patil,Nicholas Rafaels,Anne Richmond,Jonathan A. Shortt,Peter Straub,Ran Tao,Brett R. Vanderwerff,Kathleen C. Barnes,Marike Boezen,Zhengming Chen,Chia-Yen Chen,Judy H. Cho,George Davey Smith,Hilary K. Finucane,Lude Franke,Andrea Ganna,Tom R. Gaunt,Tian Ge,Hailiang Huang,Jennifer E. Huffman,Jukka Koskela,Clara Lajonchere,Matthew Law,Liming Li,Cecilia M. Lindgren,Ruth J. F. Loos,Stuart MacGregor,Koichi Matsuda,Catherine M. Olsen,David J. Porteous,Jordan A. Shavit,Harold Snieder,Richard C. Trembath,Judith M. Vonk,David C. Whiteman,Stephen J. Wicks,Cisca Wijmenga,John Wright,Jie Zheng,Xiang Zhao,Michael Boehnke,Daniel H. Geschwind,Caroline Hayward,Eimear E. Kenny,Yen-Feng Lin,Hilary C. Martin,Sarah E. Medland,Aarno Palotie,Bogdan Pasaniuc,Kari Stefansson,David A. van Heel,Robin G. Walters,Sebastian Zöllner,Alicia R. Martin,Mark J. Daly,Benjamin M. Neale +125 more
TL;DR: In this article , the authors used data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodological considerations and polygenic risk scores (PRSs) performance in 9 different biobanks for 14 disease endpoints.
Posted ContentDOI
MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways
Yoonsu Cho,Philip C Haycock,Eleanor Sanderson,Tom R. Gaunt,Jie Zheng,Andrew P. Morris,George Davey Smith,Gibran Hemani +7 more
TL;DR: A multi-trait pleiotropy model of the heterogeneity in the exposure-outcome analysis due to pathways through candidate traits and adjustment for pleiotropic pathways reduced the heterogeneity across the analyses.