Amand F. Schmidt

TL;DR: This approach identified 13 new loci at genome-wide significance, 12 of which were on the previous list of loci meeting the 5% FDR threshold, thus providing strong support that the remaining loci identified by FDR represent genuine signals.

TL;DR: Evidence from this large-scale human genetic and metabolomic study is consistent with a causal role of BCAA metabolism in the aetiology of type 2 diabetes.

TL;DR: PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes.

TL;DR: Given that modern healthcare research typically includes thousands of subjects focusing on the normality assumption is often unnecessary, does not guarantee valid results, and worse may bias estimates due to the practice of outcome transformations, this commentary explains and illustrates that in large data settings, such transformations are often unnecessary.

TL;DR: A large number of trials randomised participants to alirocumab, three trials to bococizumab, one to RG7652, and four to evolocumab found that PCSK9 inhibitors appeared to have a stronger protective effect on CVD risk, although with considerable uncertainty.