J
Jie Zheng
Researcher at University of Bristol
Publications - 127
Citations - 9389
Jie Zheng is an academic researcher from University of Bristol. The author has contributed to research in topics: Mendelian randomization & Medicine. The author has an hindex of 22, co-authored 76 publications receiving 4852 citations. Previous affiliations of Jie Zheng include Medical Research Council.
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Journal ArticleDOI
Using genetic variation to disentangle the complex relationship between food intake and health outcomes
Nicola Pirastu,Ciara McDonnell,Eryk J. Grzeszkowiak,Ninon Mounier,Fumio Imamura,Jordi Merino,Felix R. Day,Jie Zheng,Nele Taba,Maria Pina Concas,Linda Repetto,Katherine A. Kentistou,Antonietta Robino,Tõnu Esko,Peter K. Joshi,Krista Fischer,Ken K. Ong,Tom R. Gaunt,Zoltán Kutalik,John R. B. Perry,James F. Wilson +20 more
TL;DR: MR analyses using SNPs which have only a direct effect on the exposure on food exposures provided unequivocal evidence of causal associations between specific eating patterns and obesity, blood lipid status, and several other risk factors and health outcomes.
Journal ArticleDOI
Platelet Glycoprotein Ib α‐Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study
Shan Luo,Sarah L. N. Clarke,Athimalaipet V Ramanan,Susan D. Thompson,Carl D. Langefeld,Miranda C. Marion,Alexei A. Grom,C. Mary Schooling,Tom R. Gaunt,Shiu Lun Au Yeung,Jie Zheng +10 more
TL;DR: To ascertain the role of platelet glycoprotein Ib α‐chain (GPIbα) plasma protein levels in cardiovascular, autoimmune, and autoinflammatory diseases and whether its effects are mediated by platelet count is investigated.
Journal ArticleDOI
Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study.
TL;DR: It is suggested that lifelong exposure to elevated volumes of VAT might increase the risk of pancreatic cancer and lung squamous-cell carcinoma, highlighting the importance of revealing the underlying mechanisms for intervention targets.
Posted ContentDOI
Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis
James Yarmolinsky,Caroline L Relton,Artitaya Lophatananon,Kenneth Muir,Usha Menon,Aleksandra Gentry-Maharaj,Axel Walther,Jie Zheng,Peter A. Fasching,Wei Zheng,Woo Yin Ling,Jenny Chang-Claude,Jenny Chang-Claude,Sue K. Park,Byoung Gie Kim,Ji Yeob Choi,Boyoung Park,George Davey Smith,Richard M. Martin,Sarah J Lewis +19 more
TL;DR: A comprehensive examination of possible etiological drivers of ovarian carcinogenesis supports a causal role for few of these factors in epithelial ovarian cancer and suggests distinct etiologies across histotypes.
Journal ArticleDOI
A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer.
Aayah Nounu,Aayah Nounu,Alexander Greenhough,Alexander Greenhough,Kate J. Heesom,Rebecca C Richmond,Jie Zheng,Stephanie J. Weinstein,Demetrius Albanes,John A. Baron,John L. Hopper,John L. Hopper,Jane C. Figueiredo,Jane C. Figueiredo,Polly A. Newcomb,Polly A. Newcomb,Noralane M. Lindor,Graham Casey,Elizabeth A. Platz,Loic Le Marchand,Cornelia M. Ulrich,Christopher I. Li,Fränzel J.B. van Duijnhoven,Andrea Gsur,Peter T. Campbell,Victor Moreno,Pavel Vodicka,Pavel Vodicka,Pavel Vodicka,Ludmila Vodickova,Ludmila Vodickova,Ludmila Vodickova,Hermann Brenner,Jenny Chang-Claude,Jenny Chang-Claude,Michael Hoffmeister,Lori C. Sakoda,Lori C. Sakoda,Martha L. Slattery,Robert E. Schoen,Marc J. Gunter,Sergi Castellví-Bel,Hyeong Rok Kim,Sun-Seog Kweon,Andrew T. Chan,Li Li,Wei Zheng,D. Timothy Bishop,Daniel D. Buchanan,Daniel D. Buchanan,Graham G. Giles,Graham G. Giles,Stephen B. Gruber,Gad Rennert,Zsofia K. Stadler,Tabitha A. Harrison,Yi Lin,Temitope O. Keku,Michael O. Woods,Clemens Schafmayer,Bethany Van Guelpen,Steven Gallinger,Heather Hampel,Sonja I. Berndt,Paul D.P. Pharoah,Annika Lindblom,Annika Lindblom,Alicja Wolk,Alicja Wolk,Anna H. Wu,Emily White,Emily White,Ulrike Peters,Ulrike Peters,David A. Drew,Dominique Scherer,Justo Lorenzo Bermejo,Ann C. Williams,Caroline L Relton +78 more
TL;DR: In this article, the authors combined a proteomic approach with Mendelian randomization (MR) to identify possible new aspirin targets that decrease colorectal cancer (CRC) risk.