J
Jie Zheng
Researcher at University of Bristol
Publications - 127
Citations - 9389
Jie Zheng is an academic researcher from University of Bristol. The author has contributed to research in topics: Mendelian randomization & Medicine. The author has an hindex of 22, co-authored 76 publications receiving 4852 citations. Previous affiliations of Jie Zheng include Medical Research Council.
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Journal ArticleDOI
The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study.
Jie Zheng,Jie Zheng,Marie-Jo Brion,John P. Kemp,John P. Kemp,Nicole M. Warrington,Maria Carolina Borges,Maria Carolina Borges,Gibran Hemani,Gibran Hemani,Tom G. Richardson,Tom G. Richardson,Humaira Rasheed,Zhen Qiao,Philip C Haycock,Philip C Haycock,Mika Ala-Korpela,George Davey Smith,George Davey Smith,Jon H Tobias,David M. Evans,David M. Evans +21 more
TL;DR: The results suggest that effects of statins on eBMD and total body BMD are at least partly due to their LDL‐C lowering effect, and the potential role of modifying plasma lipid levels in treating osteoporosis is examined.
Journal ArticleDOI
A phenome-wide Mendelian randomization study of pancreatic cancer using summary genetic data
Ryan Langdon,Rebecca C Richmond,Gibran Hemani,Jie Zheng,Kaitlin H Wade,Robert Carreras-Torres,Mattias Johansson,Paul Brennan,Robyn E Wootton,Marcus R. Munafò,George Davey Smith,Caroline L Relton,Emma E. Vincent,Richard M. Martin,Philip C Haycock +14 more
TL;DR: Markers of adiposity (BMI and hip circumference) are potential intervention targets for pancreatic cancer prevention and further clarification of the causal relevance of the fibrinogen-cleavage peptides and O-sulfo-l-tyrosine in pancreaticcancer etiology is required.
Journal ArticleDOI
Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome.
Denis Baird,Jimmy Z. Liu,Jie Zheng,Solveig K. Sieberts,Thanneer M. Perumal,Benjamin Elsworth,Tom G. Richardson,Chia-Yen Chen,Minerva M. Carrasquillo,Mariet Allen,Joseph S. Reddy,Philip L. De Jager,Nilufer Ertekin-Taner,Lara M. Mangravite,Ben Logsdon,K. Estrada,Philip C Haycock,Gibran Hemani,Heiko Runz,George Davey Smith,Tom R. Gaunt +20 more
TL;DR: In this article, a two-sample MR using cis-acting brain-derived expression quantitative trait loci (eQTLs) from the Accelerating Medicines Partnership for Alzheimer's Disease consortium (AMP-AD) and the CommonMind Consortium (CMC) meta-analysis study (n = 1,286) was used to predict the effects of 7,137 genes on 12 neurological and psychiatric disorders.
Journal ArticleDOI
Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Roy A Elzur,Wei Zhou,Mark J. Daly,Hilary K. Finucane,Masahiro Kanai,Kuan-Han H. Wu,Humaira Rasheed,Kristin Tsuo,Jibril Hirbo,Ying Wang,Arjun Bhattacharya,Huiling Zhao,Shinichi Namba,Ida Surakka,Brooke N. Wolford,Valeria Lo Faro,E. A. Lopera-Maya,Kristi Läll,Marie-Julie Favé,Juulia Partanen,Sinéad B. Chapman,Juha Karjalainen,Mitja I. Kurki,Mutaamba Maasha,Ben Michael Brumpton,Sameer Chavan,Tzu-Ting Chen,Michelle Daya,Yi Ding,Yen-Chen Anne Feng,L. Guare,Christopher R. Gignoux,Sarah E. Graham,Whitney E. Hornsby,Nathan Ingold,Said I. Ismail,Ruth E. Johnson,Triin Laisk,Kuang Lin,Jun Lv,Iona Y. Millwood,Sonia Moreno-Grau,K.H. Nam,Priit Palta,Anita Pandit,Michael Preuss,Chadi Saad,Shefali Setia-Verma,Unnur Thorsteinsdottir,Jasmina Uzunović,Anurag Verma,Matthew Zawistowski,Xue Zhong,Nahla Afifi,Kawthar Al-Dabhani,Asmaa A. Al Thani,Yuki Bradford,Archie Campbell,Kristy Crooks,Geertruida H. de Bock,Scott M. Damrauer,Nicholas J. Douville,Sarah Finer,Lars G. Fritsche,Eleni Fthenou,G. Gonzalez-Arroyo,Chris Griffiths,Yu Guo,Karen A. Hunt,Alexander G. Ioannidis,Nomdo M. Jansonius,Takahiro Konuma,Ming Ta Michael Lee,Arturo Lopez-Pineda,Yutaka Matsuda,Riccardo E. Marioni,Babak Motamed,M. A. Nava-Aguilar,Kensuke Numakura,Snehal Patil,Nicholas Rafaels,Anne Richmond,Agustin Rojas-Muñoz,Jonathan A. Shortt,Peter Straub,Ran Tao,Brett R. Vanderwerff,Manvi Vernekar,Yogasudha Veturi,Kathleen C. Barnes,Marike Boezen,Zhengming Chen,Chia-Yen Chen,Judy H. Cho,George Davey Smith,Lude Franke,Eric R. Gamazon,Andrea Ganna,Tom R. Gaunt,Tian Ge,Hailiang Huang,Jennifer E. Huffman,Nicholas Katsanis,Jukka Koskela,Clara Lajonchere,Matthew Law,Liming Li,Cecilia M. Lindgren,Ruth J. F. Loos,Stuart MacGregor,Koichi Matsuda,Catherine M. Olsen,David J. Porteous,Jordan A. Shavit,Harold Snieder,Tomohiro Takano,Richard C. Trembath,Judith M. Vonk,David C. Whiteman,Stephen J. Wicks,Cisca Wijmenga,John Wright,Jie Zheng,Xiang Zhou,Philip Awadalla,Michael Boehnke,Carlos Bustamante,Nancy J. Cox,Segun Fatumo,Daniel H. Geschwind,Caroline Hayward,Kristian Hveem,Eimear E. Kenny,Seunggeun Lee,Yen-Feng Lin,Hamdi Mbarek,Reedik Mägi,Hilary C. Martin,Sarah E. Medland,Yukinori Okada,Aarno Palotie,Bogdan Pasaniuc,Daniel J. Rader,Marylyn D. Ritchie,Serena Sanna,Jordan W. Smoller,Kari Stefansson,David A. van Heel,Robin G. Walters,Sebastian Zöllner,Biobank of the Americas,Biobank Japan Project,BioMe,BioVU,CanPath - Ontario Health Study,China Kadoorie Biobank Collaborative Group,Colorado Center for Personalized Medicine,deCODE Genetics,Estonian Biobank, FinnGen,Generation Scotland,Genes & Health Research Team,Lifelines,Mass General Brigham Biobank,Michigan Genomics Initiative,National Biobank of Korea,Penn Medicine Biobank,Qatar Biobank,The Qskin Sun and Health Study,Taiwan Biobank,The Hunt Study,Ucla Atlas Community Health Initiative,Uganda Genome Resource,Uk Biobank,Alicia R. Martin,Cristen J. Willer,Benjamin M. Neale +175 more
TL;DR: This article proposed a summary statistics-based quality control (QC) method, suspicious loci analysis of meta-analysis summary statistics (SLALOM), that identifies suspicious locus for meta-analytical fine-mapping by detecting outliers in association statistics.
Journal ArticleDOI
EpiGraphDB: a database and data mining platform for health data science
Yi Liu,Benjamin Elsworth,Pau Erola,Valeriia Haberland,Gibran Hemani,Matthew Lyon,Jie Zheng,Oliver Lloyd,Marina Vabistsevits,Tom R. Gaunt +9 more
TL;DR: This work developed EpiGraphDB, a graph database containing an array of different biomedical and epidemiological relationships and an analytical platform to support their use in human population health data science, and presents three case studies that illustrate the value of this platform.