J
Jieqing Chen
Researcher at University of Texas MD Anderson Cancer Center
Publications - 6
Citations - 780
Jieqing Chen is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Autophagy. The author has an hindex of 5, co-authored 6 publications receiving 653 citations.
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Journal ArticleDOI
PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines
Weiyi Peng,Chengwen Liu,Chunyu Xu,Yanyan Lou,Jieqing Chen,Yan Yang,Hideo Yagita,Willem W. Overwijk,Gregory Lizée,Laszlo Radvanyi,Patrick Hwu +10 more
TL;DR: Results imply that blocking the PD-1 pathway can increase IFN-γ at the tumor site, thereby increasing chemokine-dependent trafficking of immune cells into malignant disease sites.
Journal ArticleDOI
Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism
Yuhua Zhao,Hao Liu,Zixing Liu,Yan Ding,Susan P. LeDoux,Glenn L. Wilson,Richard Voellmy,Yifeng Lin,Wensheng Lin,Rita Nahta,Bolin Liu,Øystein Fodstad,Jieqing Chen,Yun Wu,Janet E. Price,Ming Tan +15 more
TL;DR: The findings show how glycolysis inhibition can dramatically enhance the therapeutic efficacy of trastuzumab in ErbB2-positive breast cancers, potentially useful as a strategy to overcome trastzumab resistance.
Journal ArticleDOI
Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)
Shruti Desai,Zixing Liu,Jun Yao,Nishant Patel,Jieqing Chen,Yun Wu,Erin Eun Young Ahn,Øystein Fodstad,Ming Tan +8 more
TL;DR: It is demonstrated that HSF1 is required for chemotherapeutic agent-induced cytoprotective autophagy through transcriptional up-regulation of autophagic-related gene ATG7, which plays an important role in chemoresistance.
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Analysis of the intratumoral adaptive immune response in well differentiated and dedifferentiated retroperitoneal liposarcoma.
William W. Tseng,Shruti Malu,Minying Zhang,Jieqing Chen,Geok Choo Sim,Wei Wei,Davis R. Ingram,Neeta Somaiah,Dina Lev,Raphael E. Pollock,Gregory Lizée,Laszlo Radvanyi,Patrick Hwu +12 more
TL;DR: The data suggest that an adaptive immune response is present in WD/DD retroperitoneal liposarcoma but may be hindered by TLS, among other possible microenvironmental factors; further investigation is needed.
Journal ArticleDOI
MUC1 glycopeptide epitopes predicted by computational glycomics
Wei Song,Elizabeth S. DeLyria,Jieqing Chen,Wei Huang,Jun Soo Lee,Elizabeth A. Mittendorf,Nuhad K. Ibrahim,Laszlo Radvanyi,Yunsen Li,Hongzhou Lu,Huaxi Xu,Yinqiang Shi,Lai-Xi Wang,Jeremy A. Ross,Silas P. Rodrigues,Igor C. Almeida,Xifeng Yang,Jin Qu,Nathaniel S. Schocker,Katja Michael,Dapeng Zhou +20 more
TL;DR: A library of monoclonal antibodies toward authentic MUC1 glycopeptide epitopes may be a valuable tool for studying glycan and peptide sequences in cancer, as well as reagents for diagnosis and therapy.