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Institution

Northwest Florida State College

EducationNiceville, Florida, United States
About: Northwest Florida State College is a education organization based out in Niceville, Florida, United States. It is known for research contribution in the topics: Salinity & Context (language use). The organization has 17 authors who have published 19 publications receiving 563 citations. The organization is also known as: Okaloosa-Walton College & Okaloosa-Walton Junior College.

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Journal ArticleDOI
TL;DR: In this paper, the Isthmus of Panama is shown to have been an uninterrupted chain above sea level from late Eocene until at least late Miocene times using geochemical and thermochronological data.
Abstract: The rise of the Isthmus of Panama, linked to a number of climatic, paleoceanographic, and biological events, has been studied mostly from indirect, often distal, geochemical and biotic evidence. We have upgraded existing geologic mapping in central Panama with more than 2000 field stations, over 40 petrographic analyses, and more than 30 new geochronological and thermochronological analyses. This data set suggests that the isthmus was an uninterrupted chain above sea level from late Eocene until at least late Miocene times. The basement complex of central Panama is a folded-faulted, ∼3-km-thick arc sequence, intruded by granitoid bodies and onlapped by mildly deformed upper Eocene and Oligocene strata. Six U/Pb zircon ages in the granitoids–along with published geochronological data—reveal intense late Paleocene to middle Eocene magmatism (58–39 Ma), a temporary cessation of magmatic activity between 38 and 27 Ma, and renewed magmatism between 25 and 15 Ma in a position ∼75 km south of the former magmatic axis. Thermochronological analyses in zircon (eight U-Th/He ages), and in apatite crystals (four U-Th/He ages and nine fission-track ages) obtained from a subset of 58–54 Ma granitoid bodies record a concordant Lutetian-age (47–42 Ma) cooling from ∼200 °C to ∼70 °C in ∼5 m.y., and cooling below ∼40 °C between 12 and 9 Ma. Cooling is linked to exhumation by an angular unconformity that separates the deformed basement complex below from mildly deformed, upper Eocene to Oligocene terrestrial to shallow-marine strata above. Exhumation and erosion of the basement complex are independently confirmed by lower Miocene strata that have a detrital zircon signature that closely follows the central Panama basement complex age distribution. These results greatly restrict the width and depth of the strait separating southern Central America from South America, and challenge the widely accepted notion that the Central American Seaway closed in late Pliocene time, when the ice age began.

314 citations

Journal ArticleDOI
TL;DR: It is demonstrated that HSF1 is required for chemotherapeutic agent-induced cytoprotective autophagy through transcriptional up-regulation of autophagic-related gene ATG7, which plays an important role in chemoresistance.

124 citations

Journal ArticleDOI
TL;DR: The Delaware River and Bay Estuary is one of the major urbanized estuaries of the world as mentioned in this paper, and its biogeochemistry has been relatively similar for the past two decades, using a multiple-year research database to address broad spatial and seasonal patterns of conditions in the tidal river and 120 km long saline bay.
Abstract: The Delaware River and Bay Estuary is one of the major urbanized estuaries of the world. The 100-km long tidal river portion of the estuary suffered from major summer hypoxia in the past due to municipal and industrial inputs in the urban region; the estuary has seen remarkable water quality improvements from recent municipal sewage treatment upgrades. However, the estuary still has extremely high nutrient loading, which appears to not have much adverse impact. Since the biogeochemistry of the estuary has been relatively similar for the past two decades, our multiple year research database is used in this review paper to address broad spatial and seasonal patterns of conditions in the tidal river and 120 km long saline bay. Dissolved oxygen concentrations show impact from allochthonous urban inputs and meteorological forcing as well as biological influences. Nutrient concentrations, although high, do not stimulate excessive algal biomass due to light and multiple nutrient element limitations. Since the bay does not have strong persistent summer stratification, there is little potential for bottom water hypoxia. Elevated chlorophyll concentrations do not exert much influence on light attenuation since resuspended bottom inorganic sediments dominate the turbidity. Dissolved inorganic carbon and dissolved and particulate organic carbon distributions show significant variability from watershed inputs and lesser impact from urban inputs and biological processes. Ratios of dissolved and particulate carbon, nitrogen, and phosphorus help to understand watershed and urban inputs as well as autochthonous biological influences. Owing to the relatively simple geometry of the system and localized anthropogenic inputs as well as a broad spatial and seasonal database, it is possible to develop these biogeochemical trends and correlations for the Delaware Estuary. We suggest that this biogeochemical perspective allows a revised evaluation of estuarine eutrophication that should have generic value for understanding other estuarine and coastal waters.

81 citations

Journal ArticleDOI
TL;DR: PFOA did not impact IL‐2 production, but PFOS suppressed IL‐1 production in both a human cell line and human primary cells at dose levels within the high end of the human exposure range, demonstrating that a decrease in IL‐ 2 production is characteristic of autoimmune diseases such as systemic lupus erythematosus.
Abstract: Perfluorinated compounds, such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), have been shown to alter various immune functions suggesting they are immunotoxic. This study assessed the effects of PFOS and PFOA on interleukin (IL)-2 production in the human Jurkat T-cell line and PFOS in healthy human primary T cells. Jurkat cells were stimulated with phytohemagglutinin (PHA)/phorbol myristate acetate (PMA), anti CD-3/anti CD-28, or anti CD-3, and dosed with 0, 0.05, 0.1, 0.5, 1, 5, 10, 50, 75, or 100 μg ml−1 PFOS or 0, 0.005, 0.01, 0.05, 0.1, 0.5, 1, 5, or 10 μg ml−1 PFOA. Jurkat cells stimulated with PHA/PMA or anti CD-3 exhibited decreased IL-2 production beginning at 50 μg PFOS ml−1 and 5 μg PFOS ml−1 respectively, but stimulation with anti-CD3/anti-CD28 resulted in no changes compared with the control. Addition of the PPAR-alpha antagonist GW6471 to PFOS-dosed cells stimulated with PHA/PMA resulted in decreases in IL-2 production starting at 50 μg PFOS ml−1, which suggests PFOS affected T-cell IL-2 production via PPAR-alpha-independent mechanisms. Exposure to PFOA, PFOA + GW6471, or PFOS + PFOA in Jurkat cells resulted in no significant differences in IL-2 production. In vitro dosing studies using healthy primary human CD4+ T cells were consistent with the Jurkat results. These data demonstrated that PFOA did not impact IL-2 production, but PFOS suppressed IL-2 production in both a human cell line and human primary cells at dose levels within the high end of the human exposure range. A decrease in IL-2 production is characteristic of autoimmune diseases such as systemic lupus erythematosus and should be further investigated.

53 citations

Journal ArticleDOI
TL;DR: Rheological measurements indicate that nanoparticle-mediated increases in hydrogel elastic modulus can exceed the maximum modulus that can be obtained through purely chemical crosslinking, and a strong role for pseudo crossl linking facilitated by polymer–particle interactions on the observed enhancements in elastic moduli is demonstrated.
Abstract: Over the past few decades, research studies have established that the mechanical properties of hydrogels can be largely impacted by the addition of nanoparticles. However, the exact mechanisms behind such enhancements are not yet fully understood. To further explore the role of nanoparticles on the enhanced mechanical properties of hydrogel nanocomposites, we used chemically crosslinked polyacrylamide hydrogels incorporating silica nanoparticles as the model system. Rheological measurements indicate that nanoparticle-mediated increases in hydrogel elastic modulus can exceed the maximum modulus that can be obtained through purely chemical crosslinking. Moreover, the data reveal that nanoparticle, monomer, and chemical crosslinker concentrations can all play an important role on the nanoparticle mediated-enhancements in mechanical properties. These results also demonstrate a strong role for pseudo crosslinking facilitated by polymer–particle interactions on the observed enhancements in elastic moduli. Taken together, our work delves into the role of nanoparticles on enhancing hydrogel properties, which is vital to the development of hydrogel nanocomposites with a wide range of specific mechanical properties.

46 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20214
20203
20191
20181
20161
20151