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Nathaniel S. Schocker
Researcher at University of Texas at El Paso
Publications - 14
Citations - 262
Nathaniel S. Schocker is an academic researcher from University of Texas at El Paso. The author has contributed to research in topics: Chagas disease & Glycan. The author has an hindex of 7, co-authored 13 publications receiving 214 citations. Previous affiliations of Nathaniel S. Schocker include University of Texas System & Massachusetts Institute of Technology.
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Journal ArticleDOI
Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses
Xueyun Zheng,Xing Zhang,Nathaniel S. Schocker,Ryan S. Renslow,Daniel J. Orton,Jamal Khamsi,Roger A. Ashmus,Igor C. Almeida,Keqi Tang,Catherine E. Costello,Richard D. Smith,Katja Michael,Erin S. Baker +12 more
TL;DR: Ims-MS results showed significant differences for the glycan structural isomers when analyzed in positive and negative polarity and complexed with different metal cations, and suggest that specific metal ions or ion polarities could be used to target and baseline separate glycan isomers of interest with IMS-MS.
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An α-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major.
Eva Iniguez,Nathaniel S. Schocker,Krishanthi Subramaniam,Susana Portillo,Alba Montoya,Waleed S. Al-Salem,Caresse L. Torres,Felipe Rodriguez,Otacilio C. Moreira,Alvaro Acosta-Serrano,Katja Michael,Igor C. Almeida,Rosa A. Maldonado +12 more
TL;DR: It is proposed that NGP5B is an attractive candidate for the study of potential synthetic α-Gal-neoglycoprotein-based vaccines against L. major, and a robust humoral and cellular immune response with production of high levels of protective lytic anti-α-Gal antibodies and induction of Th1 cytokines is observed.
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Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease
Roger A. Ashmus,Nathaniel S. Schocker,Yanira Cordero-Mendoza,Alexandre F. Marques,Erika Y. Monroy,Andrew Pardo,Luis Izquierdo,Montserrat Gállego,Joaquim Gascon,Igor C. Almeida,Katja Michael +10 more
TL;DR: A synthetic glycoarray containing non-reducing α-galactopyranosyl moieties related to mucin O-glycans of the parasite Trypanosoma cruzi revealed the disaccharide Galα(1,3)Galβ as the immunodominant glycotope, which may be employed as a diagnostic antigen for Chagas disease.
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Synthesis of Galα(1,3)Galβ(1,4)GlcNAcα-, Galβ(1,4)GlcNAcα- and GlcNAc-containing neoglycoproteins and their immunological evaluation in the context of Chagas disease
Nathaniel S. Schocker,Susana Portillo,Carlos R. N. Brito,Alexandre F. Marques,Igor C. Almeida,Katja Michael +5 more
TL;DR: The results indicate that the synthetic Galα (1,3)Galβ(1,4)GlcNAcα-BSA glycotope coupled to a carrier protein could be a potential diagnostic and vaccine candidate for ChD and highlights the importance of the terminal Galα moiety for recognition by Ch anti-α-Gal Abs and the lack of Abs against nonself Galβ( 1,4), Glcnacα and Glc NAcα glycotopes.
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MUC1 glycopeptide epitopes predicted by computational glycomics
Wei Song,Elizabeth S. DeLyria,Jieqing Chen,Wei Huang,Jun Soo Lee,Elizabeth A. Mittendorf,Nuhad K. Ibrahim,Laszlo Radvanyi,Yunsen Li,Hongzhou Lu,Huaxi Xu,Yinqiang Shi,Lai-Xi Wang,Jeremy A. Ross,Silas P. Rodrigues,Igor C. Almeida,Xifeng Yang,Jin Qu,Nathaniel S. Schocker,Katja Michael,Dapeng Zhou +20 more
TL;DR: A library of monoclonal antibodies toward authentic MUC1 glycopeptide epitopes may be a valuable tool for studying glycan and peptide sequences in cancer, as well as reagents for diagnosis and therapy.