J
Jimmy K. Eng
Researcher at University of Washington
Publications - 171
Citations - 37832
Jimmy K. Eng is an academic researcher from University of Washington. The author has contributed to research in topics: Mass spectrometry & Proteome. The author has an hindex of 77, co-authored 168 publications receiving 35701 citations. Previous affiliations of Jimmy K. Eng include Oregon Health & Science University & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
MRMer, an interactive open source and cross-platform system for data extraction and visualization of multiple reaction monitoring experiments
Daniel Martin,Ted Holzman,Damon May,Amelia Peterson,Ashley Eastham,Jimmy K. Eng,Jimmy K. Eng,Martin W. McIntosh +7 more
TL;DR: An interactive software platform, called MRMer, is developed, for managing highly complex MRM-MS experiments, including quantitative analyses using heavy/light isotopic peptide pairs, and incorporates features that permit the quantitative analysis experiments including heavy and light isotopic Peptide pairs.
Journal ArticleDOI
Proteomic Analysis of the Intestinal Epithelial Cell Response to Enteropathogenic Escherichia coli
Philip R. Hardwidge,Isabel Rodríguez-Escudero,David L Goode,Sam Donohoe,Jimmy K. Eng,David R. Goodlett,Reudi Aebersold,B. Brett Finlay +7 more
TL;DR: The identified changes extend cytoskeletal observations made in less relevant cell types and generate testable hypotheses with regard to host proteins potentially involved in EPEC-induced diarrhea to provide a framework for future biochemical analyses of host-pathogen interactions.
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Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.
See-Yeun Ting,Dustin E Bosch,Sarah M. Mangiameli,Matthew C. Radey,Shuo Huang,Young-Jun Park,Katherine A. Kelly,Szymon Krzysztof Filip,Young Ah Goo,Jimmy K. Eng,Marc Allaire,David Veesler,Paul A. Wiggins,S. Brook Peterson,Joseph D. Mougous +14 more
TL;DR: It is demonstrated that one such toxin from Serratia proteamaculans interrupts the division of competing cells by modifying the essential bacterial tubulin-like protein, FtsZ, adjacent to its protomer interface, blocking its capacity to polymerize.
Journal ArticleDOI
Cross-linking Measurements of In Vivo Protein Complex Topologies
Chunxiang Zheng,Li Yang,Michael R. Hoopmann,Jimmy K. Eng,Xiaoting Tang,Chad R. Weisbrod,James E. Bruce +6 more
TL;DR: In this article, an unbiased cross-linking approach was used to identify protein interactions in E. coli cells, yielding the first in vivo topological data on many interactions and the largest set of identified in vivo cross-linked peptides produced to date.
Journal ArticleDOI
The Application of New Software Tools to Quantitative Protein Profiling Via Isotope-coded Affinity Tag (ICAT) and Tandem Mass Spectrometry I. Statistically Annotated Datasets for Peptide Sequences and Proteins Identified via the Application of ICAT and Tandem Mass Spectrometry to Proteins Copurifying with T Cell Lipid Rafts
Priska D. von Haller,Eugene C. Yi,Samuel Donohoe,Kelly Vaughn,Andrew Keller,Alexey I. Nesvizhskii,Jimmy K. Eng,Xiao jun Li,David R. Goodlett,Ruedi Aebersold,Julian D. Watts +10 more
TL;DR: In this article, an online micro-capillary liquid chromatography tandem mass spectrometry was performed on both avidin-affinity (ICAT-labeled) and flow-through (unlabeled).