Showing papers in "European Journal of Cancer in 1995"

TL;DR: Overall survival curves were identical in the four groups of patients, so that the three breast conserving radiosurgical procedures had the same survival rates as Halsted mastectomy, however, local recurrence rates were markedly influenced by the treatment method, patient age and specific histological features.

TL;DR: To understand the complex effects of SCFAs on carcinogenesis, it is important to study the intermediate stages of the adenoma-carcinoma sequence where a "switch" from stimulation to suppression of cell proliferation must occur.

TL;DR: The EORTC QLQ-C30 is found to be practical and valid in measuring quality of life in patients with advanced disease and to be useful to detect the effect of palliative radiotherapy over time.

TL;DR: The evidence that bile acids are involved in colonic carcinogenesis is largely circumstantial, however, it is well accepted that environmental factors, such as dietary habits influence genetic susceptibility, and Bile acids could play a promoting role in this process.

TL;DR: The molecular weight-dependence of tumour capture of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers was studied in vivo using subcutaneous Sarcoma 180 or B16F10 melanoma models and the ratio (accumulation index, AI) of the AUC in tumour to A UC in skeletal muscle (a typical normal tissue) increasing from six to 12 with increasing copolymer molecular weight.

TL;DR: Min mice provide a good animal model for studying the role of Apc and interacting genes in the initiation and progression of intestinal and mammary tumorigenesis and can be increased in an age-specific manner by treatment with ethylnitrosourea (ENU).

TL;DR: In this paper, a multivariate analysis based on Cox's proportional hazards regression model was performed on the most important prognostic factors and their association with invasion and death, an index was computed reflecting the risk of both invasion and malignant disease, respectively.

TL;DR: Results indicate that treatment with chimeric MAb ch14.18 can elicit some complete and partial tumour responses in neuroblastoma patients.

TL;DR: It is suggested that delivery of the NTR gene to human tumours, followed by treatment with CB1954, may provide a novel tumour gene therapy approach.

TL;DR: The 10-year results of 300 patients with ductal carcinoma in situ (DCIS) without microinvasion are reported; 167 treated with mastectomy and 133 treated with excision and radiation therapy.

TL;DR: To predict the biological and pharmacological effects of the blocking of this protein, mice with a genetic disruption of the drug-transporting mdr1a P-glycoprotein are generated and are found to accumulate much higher levels of substrate drugs in the brain, and have markedly slower elimination of these drugs from the circulation.

TL;DR: In this article, a review of 397 cases of non-metastatic male breast cancer (MBC) treated in 14 French regional cancer centres were reviewed and the median age was 64 years (range 25-93).

TL;DR: This review summarises the results of research in animals and humans of these compounds in preventing tumours of the colorectum of nonsteroidal anti-inflammatory drugs.

TL;DR: High levels of urinary 8OHdG were found in patients subjected to whole body irradiation, and in patients receiving chemotherapy with various cytostatic agents and the potential use of the method for detecting increased urinary 8 OHdG excretion and conditions associated with increased oxidative DNA damage in humans is discussed.

TL;DR: The preliminary results support the value of serum S100 as an adjunct to the clinical staging and monitoring of metastatic malignant melanoma.

TL;DR: This work focuses on growth factor dependencies in the SH-SY5Y system, and compares that to the normal situation, i.e. growth factor control of sympathetic neuronal and neuroendocrine differentiation during human and rat embryogenesis.

TL;DR: Pelvic nerve-sparing procedures with lateral dissection for lower rectal cancer is the most promising surgery, guaranteeing both adequate lymphadenectomy and preservation of urinary function.

TL;DR: The most accurate predictor of response in the present study appeared to be the response to chemotherapy treatment itself, as well as possibly drug resistance markers.

TL;DR: It remains to be determined if tumours in one group ever evolve into a less unfavourable group, but current evidence suggests that they are distinct genetically.

TL;DR: The Netherlands Cancer Registry as discussed by the authors is a cancer registry that covers the whole Dutch population (approximately 15 million people) and receives data on incident cancer cases from nine autonomous regional cancer registries.

TL;DR: The results indicate that determination of serum YKL-40 can be used as a prognostic marker related to the extent of disease and survival of patients with recurrence of breast cancer and in evaluating potential metastatic spread.

TL;DR: A separate study showed that low thymidylate synthase levels appeared to be an independent prognostic factor for adjuvant therapy, and a significant relationship was observed with outcome of treatment; when thymidine synthase Levels were high and inhibition was low, no response was observed.

TL;DR: Since 1980, a nationwide registry of childhood malignancies has been established in the Federal Republic of Germany and combines features of a population-based and a hospital-based registry.

TL;DR: A strong statistical association between TS expression and resistance to therapy has been found and confirmation of these results in a larger cohort could lead to a scientific rationale for deciding upon specific therapy for patients with disseminated colorectal cancers.

TL;DR: The first analysis of a randomised multicentre, international phase III study was presented in this paper, where 439 patients with previously untreated advanced colorectal cancer were randomised to Tomudex 3.0 mg/m2 given once every 3 weeks or 5-fluorouracil (5-FU) 425 mg /m2 and leucovorin (LV) 20 mg/ m2 for 5 days (the Mayo regimen), given every 4-5 weeks.

TL;DR: Epidermal growth factor receptor receptor levels were evaluated in paraffin-embedded tumour specimens of non-small cell lung cancer (NSCLC) from 176 patients who underwent surgical resection and EGFr immunoreactivity was significantly higher in squamous than in non-squamous cell carcinomas.

TL;DR: In this paper, an active specific immunization (ASI) procedure with two types of autologous tumor cell vaccines (ATV) is tested for adjuvant immunotherapy of resected colorectal carcinoma to provide preliminary information on local immunological skin responses, side effects and two year survival rates.

TL;DR: The National Registry of Childhood Tumours contains population-based data on childhood cancers diagnosed throughout Great Britain from 1962 onwards and incidence rates for 1978-1987 are presented and other uses of the data are described.

TL;DR: Frozen tissue from primary tumours of 152 premenopausal breast cancer patients, who participated in a trial comparing radiotherapy with adjuvant chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil, CMF), was analysed for c-erbB-2 protein expression, measured by flow cytometry.

TL;DR: The novel regimen of epirubicin, cisplatin and continuous infusional 5-fluorouracil (5-FU) (ECF) in patients with advanced hepatobiliary tumours was well tolerated with minimal haematological and non-haematologically toxicity.