J
Joana R. Guedes
Researcher at University of Coimbra
Publications - 26
Citations - 1152
Joana R. Guedes is an academic researcher from University of Coimbra. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 16 publications receiving 786 citations. Previous affiliations of Joana R. Guedes include Harvard University.
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miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production
TL;DR: Results show that miR‐155 has a pro‐inflammatory role in microglia and is necessary for the progression of the immune response through the modulation of SOCS‐1, suggesting that, in a chronic inflammatory context, miR •155 inhibition can have a neuroprotective effect.
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Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
Ana L. Cardoso,Adelaide Fernandes,Juan Antonio Aguilar-Pimentel,Martin Hrabé de Angelis,Joana R. Guedes,Maria Alexandra Brito,Saida Ortolano,Giovambattista Pani,Sophia Athanasopoulou,Efstathios S. Gonos,Markus Schosserer,Johannes Grillari,Pärt Peterson,Bilge Guvenc Tuna,Soner Dogan,Angelika Meyer,Ronald van Os,Anne-Ulrike Trendelenburg +17 more
TL;DR: Biomarker panels for frailty would be of high value and better than single markers.
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Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model
Joana R. Guedes,Carlos Custódia,Ricardo Jorge Silva,Luís Pereira de Almeida,Maria C. Pedroso de Lima,Ana L. Cardoso +5 more
TL;DR: Early miR-155 and c-Jun upregulation in the 3xTg AD mice, as well as in Aβ-activated microglia and astrocytes, are suggested to be contributing to the production of inflammatory mediators such as IL-6 and IFN-β.
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Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
TL;DR: The roles of the chemokine/chemokine receptor pairs CCL2/ CCR2, CX3CL1/CX3CR1, CCL5/CCR5, CxCL10/C XCR3 and CXCL1-CXCR2 are focused on, highlighting important knowledge gaps in this field.
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Involvement of microRNA in microglia-mediated immune response.
TL;DR: The role of specific miRNAs in the maintenance and switching of microglia activation states are discussed and the potential of this class of nucleic acids both as biomarkers of inflammation and new therapeutic tools for the modulation ofmicroglia behavior in the CNS is illustrated.