J
Jochen Hess
Researcher at German Cancer Research Center
Publications - 125
Citations - 6990
Jochen Hess is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 39, co-authored 110 publications receiving 6071 citations. Previous affiliations of Jochen Hess include University of Würzburg & Heidelberg University.
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Journal ArticleDOI
CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice
Tatjana Samardzic,Judith Gerlach,Kerstin Müller,Dragan Marinkovic,Jochen Hess,Lars Nitschke,Thomas Wirth +6 more
TL;DR: The studies suggest that the B cell differentiation defect observed in BOB.1/OBF.1–/– mice is BCR‐signal dependent, however, the impairment in germinal center formation is caused by a different mechanism.
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Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity
Elena De Vita,Elena De Vita,Peter Schüler,Scott Lovell,Jasmin Lohbeck,Sven Kullmann,Eitan Rabinovich,Amiram Sananes,Bernd Heßling,Veronique Hamon,Niv Papo,Jochen Hess,Jochen Hess,Edward W. Tate,Nikolas Gunkel,Aubry K. Miller +15 more
TL;DR: This work introduces a class of depsipeptidic KLK6 inhibitors, discovered via high-throughput screening, which were found to function as substrate mimics that transiently acylate the catalytic serine of KLK 6.
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Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation
Astrid Riehl,Tobias Bauer,Benedikt Brors,Hauke Busch,Hauke Busch,Regina Mark,Regina Mark,Julia Németh,Christoffer Gebhardt,Angelika Bierhaus,Peter P. Nawroth,Roland Eils,Roland Eils,Rainer König,Rainer König,Peter Angel,Jochen Hess,Jochen Hess +17 more
TL;DR: The data support the model that engagement of Rage converts a transient cellular stimulation into sustained cellular dysfunction and highlight a novel role of the Rb-E2f pathway in Rage-dependent inflammation during pathological conditions.
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Organotypic Co-Cultures as a Novel 3D Model for Head and Neck Squamous Cell Carcinoma.
Luca Engelmann,Julia Thierauf,Julia Thierauf,Natalia Koerich Laureano,Natalia Koerich Laureano,Natalia Koerich Laureano,Hans-Juergen Stark,Elena-Sophie Prigge,Dominik Horn,Kolja Freier,Niels Grabe,Chao Rong,Chao Rong,Philippe A. Federspil,Karim Zaoui,Peter K. Plinkert,Nicole Rotter,Magnus von Knebel Doeberitz,Jochen Hess,Jochen Hess,Annette Affolter +20 more
TL;DR: The 3D-OTC model for HNSCC supports cancer cell survival and proliferation in their original microenvironment and enables investigation of invasive cancer growth and might, in the future, serve as a platform to perform sensitivity testing upon treatment to predict therapy response.
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Estrogen Receptor Signaling in Radiotherapy: From Molecular Mechanisms to Clinical Studies.
Chao Rong,Étienne Fasolt Richard Corvin Meinert,Étienne Fasolt Richard Corvin Meinert,Jochen Hess,Jochen Hess +4 more
TL;DR: Pre-clinical and clinical studies that evaluate the consequences of anti-estrogen and irradiation therapy in cancer, including emerging studies on head and neck cancer, are summarized to improve the understanding and development of novel therapeutic strategies for estrogen-related cancers.