J
Jochen Hess
Researcher at German Cancer Research Center
Publications - 125
Citations - 6990
Jochen Hess is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 39, co-authored 110 publications receiving 6071 citations. Previous affiliations of Jochen Hess include University of Würzburg & Heidelberg University.
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Journal ArticleDOI
A pro-tumorigenic function of S100A8/A9 in carcinogen-induced hepatocellular carcinoma.
Aurora De Ponti,Lars Wiechert,D Schneller,Tobias Pusterla,Thomas Longerich,Thomas Longerich,Nancy Hogg,Arndt Vogel,Peter Schirmacher,Jochen Hess,Jochen Hess,Peter Angel +11 more
TL;DR: It is found that tumor cell proliferation was diminished in the absence of S100A8/A9, leading to significant reduction of tumor size, demonstrating that calprotectin is required for the progression of non- inflammation driven liver tumor and might represent a therapeutic target for the treatment of HCC formed in non-cirrhotic liver.
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Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer.
B Feng,Ying Shen,Xavier Pastor Hostench,Matthias Bieg,Matthias Bieg,Michaela Plath,Naveed Ishaque,Naveed Ishaque,Roland Eils,Roland Eils,Roland Eils,Kolja Freier,Kolja Freier,Wilko Weichert,Karim Zaoui,Jochen Hess,Jochen Hess +16 more
TL;DR: The data highlight a complex interplay between genetic and epigenetic events in the establishment of the tumor immune phenotype and provide compelling experimental evidence that a patient with squamous cell carcinoma of the head and neck at higher risk for ICI treatment failure might benefit from a combination with EGFR inhibition.
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Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts
Marion Schumacher,Christian Schuster,Zbigniew Rogon,Tobias Bauer,Nevisa Caushaj,Sebastian Baars,Sibylle Szabowski,Christine Bauer,Marina Schorpp-Kistner,Jochen Hess,Jochen Hess,Stefan Holland-Cunz,Erwin F. Wagner,Roland Eils,Peter Angel,Bettina Hartenstein +15 more
TL;DR: Results imply that mesenchymal JNK has a pivotal role in the paracrine cross talk between dermal fibroblasts and epidermal keratinocytes during wound healing, and demonstrate that efficient keratinocyte terminal differentiation requires constant presence of JNK-dependent and fibroblast-derived soluble factors.
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Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients
Efterpi Kostareli,Thomas Hielscher,Manuela Zucknick,Lorena Baboci,Gunnar Wichmann,Dana Holzinger,Oliver Mücke,Michael Pawlita,Annarosa Del Mistro,Paolo Boscolo-Rizzo,Maria Cristina Da Mosto,Giancarlo Tirelli,Peter Plinkert,Andreas Dietz,Christoph Plass,Dieter Weichenhan,Jochen Hess +16 more
TL;DR: The MS and the MMSS exhibit an excellent performance as prognosticators for survival, which is not limited by the anatomical site, and both could be implemented in future clinical trials.
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Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo.
Julia S. Leibold,Astrid Riehl,Jan Hettinger,Michael Durben,Jochen Hess,Jochen Hess,Peter Angel +6 more
TL;DR: It is shown that RAGE expression in cutaneous keratinocytes modulates the strength and kinetics of acute inflammation and supports the maintenance of epidermal keratinocyte activation, and the central role of RAGE in paracrine communication between Keratinocytes and stromal immune cells is supported.