Jochen Hess

TL;DR: The data provide experimental evidence that specific inhibition of the KLK6-PAR1 axis may interfere with the deleterious effect of tumor-microenvironment interaction and represent a potential option for translational melanoma research.

TL;DR: It is shown that TGF-β2 mRNA expression and secretion increased in murine HSCs and hepatocytes over time in culture and were found in the human-derived HSC cell line LX-2, and suggests TGF -β2 as a promising therapeutic target for tackling fibrosis and HCC.

TL;DR: In this article, the expression of Kallikrein-related peptidase 6 (KLK6) is a common feature for many human malignancies and numerous studies evaluated KLK6 as a promising biomarker for early diagnosis or unfavorable prognosis.

TL;DR: This review summarizes the most recent advances in the understanding of the molecular principles of HPV-related OPSCC, mainly based on functional genomic approaches, but also emphasizes the significant role played by the tumor microenvironment, especially the immune system, for improved clinical outcome and differential sensitivity ofHPV-related tumors to current treatment options.

TL;DR: This study successfully developed and independently validated a workflow for the typing of PTC clinical samples into CLIP2-positive and -negative cases and provided first insights into the ClIP2 interactome in the context of radiation-associated PTC.