J
Jochen Hess
Researcher at German Cancer Research Center
Publications - 125
Citations - 6990
Jochen Hess is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 39, co-authored 110 publications receiving 6071 citations. Previous affiliations of Jochen Hess include University of Würzburg & Heidelberg University.
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Journal ArticleDOI
AP-1 and Cbfa/Runt Physically Interact and Regulate Parathyroid Hormone-dependent MMP13 Expression in Osteoblasts through a New Osteoblast-specific Element 2/AP-1 Composite Element *
TL;DR: In this article, the expression of MMP13 (collagenase-3), a member of the matrix metalloproteinase family, is increased in vivo as well as in cultured osteosarcoma cell lines by parathyroid hormone (PTH), a major regulator of calcium homeostasis.
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The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer.
Gunnar Wichmann,Maciej Rosolowski,Knut Krohn,Markus Kreuz,Andreas Boehm,Anett Reiche,Ulrike Scharrer,Dirk Halama,Julia Bertolini,Ulrike Bauer,Dana Holzinger,Michael Pawlita,Jochen Hess,Christoph Engel,Dirk Hasenclever,Markus Scholz,Peter Ahnert,Holger Kirsten,Alexander Hemprich,Christian Wittekind,Olf Herbarth,Friedemann Horn,Andreas Dietz,Markus Loeffler +23 more
TL;DR: It is found that tumors with transcriptionally inactive HPV16 (DNA+ RNA‐) are similar to HPV‐negative (DNA‐) tumors regarding gene expression and frequency of TP53 mutations and that an immune response‐related gene expression cluster is associated with lymph node metastasis, independent of HPV16 status.
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Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment
Elad Horwitz,Ilan Stein,Mariacarla Andreozzi,Julia Németh,Avivit Shoham,Orit Pappo,Nora Schweitzer,Luigi Tornillo,Naama Kanarek,Luca Quagliata,Farid Zreik,Rinnat M. Porat,Rutie Finkelstein,Hendrik Reuter,Ronald Koschny,Tom M. Ganten,Carolin Mogler,Oren Shibolet,Jochen Hess,Kai Breuhahn,Myriam Grunewald,Peter Schirmacher,Arndt Vogel,Luigi Terracciano,Peter Angel,Yinon Ben-Neriah,Eli Pikarsky +26 more
TL;DR: FISH analysis of a retrospective patient cohort showed markedly improved survival of sorafenib-treated patients with V EGFA-amplified HCCs, suggesting that VEGFA amplification is a potential biomarker for HCC response to VEGF-A-blocking drugs.
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Genomic and Expression Profiling of Glioblastoma Stem Cell–Like Spheroid Cultures Identifies Novel Tumor-Relevant Genes Associated with Survival
Aurélie Ernst,Stefanie Hofmann,Rezvan Ahmadi,Natalia Becker,Andrey Korshunov,Andrey Korshunov,Felix Engel,Christian Hartmann,Christian Hartmann,Jörg Felsberg,Michael Sabel,Heike Peterziel,Moritz Durchdewald,Jochen Hess,Sebastian Barbus,Benito Campos,Anna Starzinski-Powitz,Andreas Unterberg,Guido Reifenberger,Peter Lichter,Christel Herold-Mende,Bernhard Radlwimmer +21 more
TL;DR: A set of novel candidate genes that likely play a role in glioblastoma pathogenesis are identified and implicate AJAP1, EMP3, and PDPN as molecular markers associated with the clinical outcome of glioma patients.
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Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion.
Britta Klucky,Regina Mueller,Ingeborg Vogt,Sibylle Teurich,Bettina Hartenstein,Kai Breuhahn,Christa Flechtenmacher,Peter Angel,Jochen Hess +8 more
TL;DR: KlK6 up-regulation in squamous skin tumors of human patients and in tumors of other epithelial tissues is shown and enhanced epidermal keratinocyte proliferation and migration in concert with decreased E-cadherin protein levels are confirmed in an in vivo Klk6 transgenic mouse model.