J
Joel K. Elmquist
Researcher at University of Texas Southwestern Medical Center
Publications - 245
Citations - 51441
Joel K. Elmquist is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Leptin & Hypothalamus. The author has an hindex of 105, co-authored 235 publications receiving 47755 citations. Previous affiliations of Joel K. Elmquist include University of Utah & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
Richard M. Chemelli,Jon T. Willie,Christopher M. Sinton,Joel K. Elmquist,Thomas E. Scammell,Charlotte E. Lee,James A. Richardson,S. Clay Williams,Yumei Xiong,Yaz Y. Kisanuki,Thomas Fitch,Masamitsu Nakazato,Robert E. Hammer,Clifford B. Saper,Masashi Yanagisawa +14 more
TL;DR: It is proposed that orexin regulates sleep/wakefulness states, and that Orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation.
Journal ArticleDOI
Differential expression of orexin receptors 1 and 2 in the rat brain.
Jacob Marcus,Carl J. Aschkenasi,Charlotte E. Lee,Richard M. Chemelli,Clifford B. Saper,Masashi Yanagisawa,Joel K. Elmquist +6 more
TL;DR: The differential distribution of oxin receptors is consistent with the proposed multifaceted roles of orexin in regulating homeostasis and may explain the unique role of the OX2R receptor in regulating sleep state stability.
Journal ArticleDOI
Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21
Takeshi Inagaki,Paul A. Dutchak,Guixiang Zhao,Xunshan Ding,Laurent Gautron,Vinay Parameswara,Yong Li,Regina Goetz,Moosa Mohammadi,Victoria Esser,Joel K. Elmquist,Robert D. Gerard,Shawn C. Burgess,Robert E. Hammer,David J. Mangelsdorf,Steven A. Kliewer +15 more
TL;DR: These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation.
Journal ArticleDOI
From lesions to leptin: hypothalamic control of food intake and body weight.
TL;DR: The availability of these molecular tools, coupled with tract tracing, has resulted in striking progress in dissecting an extensive network of hypothalamic circuitry that regulates feeding, and the outline of the hypothalamic system for regulation of feeding is now more clear.
Journal ArticleDOI
The need to feed: Homeostatic and hedonic control of eating
TL;DR: The role played in homeostatic regulation of feeding by systemic mediators such as leptin and ghrelin are examined, which act on brain systems utilizing neuropeptide Y, agouti-related peptide, melanocortins, orexins, and melanin concentrating hormone, among other mediators.