J
Joel K. Elmquist
Researcher at University of Texas Southwestern Medical Center
Publications - 245
Citations - 51441
Joel K. Elmquist is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Leptin & Hypothalamus. The author has an hindex of 105, co-authored 235 publications receiving 47755 citations. Previous affiliations of Joel K. Elmquist include University of Utah & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever.
TL;DR: It is suggested that NO may play an important role in thermoregulation and suggest that NO is required for the production of fever.
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VGF is Required for Obesity Induced by Diet, Gold Thioglucose Treatment, and Agouti and is Differentially Regulated in Pro-Opiomelanocortin- and Neuropeptide Y-Containing Arcuate Neurons in Response to Fasting
Seung Hahm,Csaba Fekete,Csaba Fekete,Tooru M. Mizuno,Joan Windsor,Hai Yan,Carol N. Boozer,Charlotte E. Lee,Joel K. Elmquist,Ronald M. Lechan,Charles V. Mobbs,Stephen R.J. Salton +11 more
TL;DR: A role for VGF in outflow pathways, downstream of hypothalamic and/or brainstem melanocortin 4 receptors, that project via the autonomic nervous system to peripheral metabolic tissues and regulate energy homeostasis is consistent with a role for the gene encoding the neuronal and neuroendocrine secreted polypeptide VGF.
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Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor
Christian Bjørbæk,Joel K. Elmquist,Karim El-Haschimi,Joseph Kelly,Rexford S. Ahima,Stanley M. Hileman,Jeffrey S. Flier +6 more
TL;DR: In situ hybridization histochemistry of hypothalamus from ob/ob mice and normal rats demonstrated that CNTF induced SOCS-3 mRNA in the arcuate nucleus (Arc) and strong hybridization signals were also detected in the ependymal lining of rats.
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PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.
Yong Xu,Jennifer W. Hill,Jennifer W. Hill,Makoto Fukuda,Laurent Gautron,Jong Woo Sohn,Ki Woo Kim,Charlotte E. Lee,Michelle J. Choi,Danielle A. Lauzon,Harveen Dhillon,Bradford B. Lowell,Jeffrey M. Zigman,Jean J. Zhao,Joel K. Elmquist +14 more
TL;DR: It is shown that mice with reduced PI3K activity in the ventromedial hypothalamic nucleus (VMH) are more sensitive to high-fat diet-induced obesity due to reduced energy expenditure and the acute anorexigenic effects induced by exogenous leptin were blunted in the mutant mice.
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The Fat-Brain Axis Enters a New Dimension
TL;DR: exciting new research is discussed showing that leptin directly affects the activity and synaptic input of arcuate neurons and also stimulates their growth during development.