J
Joel K. Elmquist
Researcher at University of Texas Southwestern Medical Center
Publications - 245
Citations - 51441
Joel K. Elmquist is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Leptin & Hypothalamus. The author has an hindex of 105, co-authored 235 publications receiving 47755 citations. Previous affiliations of Joel K. Elmquist include University of Utah & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis
Jari Rossi,Nina Balthasar,Nina Balthasar,David P. Olson,Michael Scott,Eric D. Berglund,Charlotte E. Lee,Michelle J. Choi,Danielle A. Lauzon,Bradford B. Lowell,Joel K. Elmquist +10 more
TL;DR: It is suggested that MC4Rs expressed by cholinergic neurons regulate energy expenditure and hepatic glucose production and provide further evidence of the dissociation in pathways mediating the effects of melanocortins on energy balance and glucose homeostasis.
Journal ArticleDOI
Unraveling the central nervous system pathways underlying responses to leptin
TL;DR: The physiological mechanisms underlying leptin action are considered, along with several novel hypothalamic neuropeptides that affect food intake and body weight, and a model linking populations of leptin-responsive neurons with effectors underlying leptin's endocrine, autonomic and behavioral effects is proposed.
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Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction
Yong Xu,Thekkethil P. Nedungadi,Liangru Zhu,Nasim C. Sobhani,Boman G. Irani,Kathryn Davis,Xiaorui Zhang,Fang Zou,Lana M. Gent,Lisa Hahner,Sohaib A. Khan,Carol F. Elias,Joel K. Elmquist,Deborah J. Clegg +13 more
TL;DR: It is demonstrated that brain-specific deletion of ERα in female mice causes abdominal obesity stemming from both hyperphagia and hypometabolism and that estrogens act on distinct hypothalamic ERα neurons to regulate different aspects of energy homeostasis and reproduction.
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Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
Hiroshi Yamamoto,Charlotte E. Lee,Jacob Marcus,T. D. Williams,J. Michael Overton,Marisol E. Lopez,Anthony N. Hollenberg,Laurie L. Baggio,Clifford B. Saper,Daniel J. Drucker,Joel K. Elmquist +10 more
TL;DR: It is reported here that centrally and peripherally administered GLP-1R agonists dose-dependently increased blood pressure and heart rate and this suggests that the central GLp-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo.
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Activation of central melanocortin pathways by fenfluramine
Lora K. Heisler,Michael A. Cowley,Laurence H. Tecott,Wei Fan,Malcolm J. Low,James L. Smart,Marcelo Rubinstein,Jeffrey B. Tatro,Jacob Marcus,Henne Holstege,Charlotte E. Lee,Roger D. Cone,Joel K. Elmquist +12 more
TL;DR: It is shown that d-FEN–induced anorexia requires activation of central nervous system melanocortin pathways and drugs targeting these downstream melanoc Cortin pathways may prove to be effective and more selective anti-obesity treatments.