J
Johannes H. Wildhaber
Researcher at University of Fribourg
Publications - 71
Citations - 3886
Johannes H. Wildhaber is an academic researcher from University of Fribourg. The author has contributed to research in topics: Asthma & Nebulizer. The author has an hindex of 29, co-authored 70 publications receiving 3677 citations. Previous affiliations of Johannes H. Wildhaber include Princess Margaret Hospital for Children & Telethon Institute for Child Health Research.
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Journal ArticleDOI
Definition, assessment and treatment of wheezing disorders in preschool children: An evidence-based approach
Paul L. P. Brand,Eugenio Baraldi,Hans Bisgaard,A. L. Boner,Jose A. Castro-Rodriguez,Adnan Custovic,J. de Blic,J. C. de Jongste,Ernst Eber,M. L. Everard,Urs Frey,Monika Gappa,Luis Garcia-Marcos,Jonathan Grigg,Warren Lenney,P. N. Le Souëf,Sheila A. McKenzie,Peter J. F. M. Merkus,Fabio Midulla,James Y. Paton,Giorgio Piacentini,Petr Pohunek,G. A. Rossi,Paul Seddon,Michael Silverman,Peter D. Sly,Stephen M. Stick,Arunas Valiulis,W.M.C. van Aalderen,Johannes H. Wildhaber,Göran Wennergren,Nicola Wilson,Zorica Zivkovic,Andrew Bush +33 more
TL;DR: Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.
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DNAH5 Mutations Are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects
Nada Hornef,Heike Olbrich,Judit Horvath,Maimoona B Zariwala,Manfred Fliegauf,Niki T. Loges,Johannes H. Wildhaber,Peadar G. Noone,Marcus P. Kennedy,Stylianos E. Antonarakis,Jean-Louis Blouin,Lucia Bartoloni,Thomas Nüsslein,Peter Ahrens,Matthias Griese,Heiner Kuhl,Ralf Sudbrak,Michael R. Knowles,Richard Reinhardt,Heymut Omran +19 more
TL;DR: DNAH5 is frequently mutated in patients with PCD exhibiting outer dynein arm defects and mutations cluster in five exons.
Journal ArticleDOI
Mislocalization of DNAH5 and DNAH9 in Respiratory Cells from Patients with Primary Ciliary Dyskinesia
Manfred Fliegauf,Heike Olbrich,Judit Horvath,Johannes H. Wildhaber,Maimoona A. Zariwala,Marcus P. Kennedy,Michael R. Knowles,Heymut Omran +7 more
TL;DR: In normal ciliated airway epithelium, DNAH5 and DNAH9 show a specific regional distribution along the ciliary axoneme, indicating the existence of at least two distinct ODA types, and immunofluorescence staining can detect ODA defects, which will possibly aid PCD diagnosis.
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Inhalation therapy in asthma: nebulizer or pressurized metered-dose inhaler with holding chamber? In vivo comparison of lung deposition in children.
TL;DR: Comparing lung deposition from a nebulizer and a pressurized metered-dose inhaler (pMDI)/holding chamber to determine their efficiency in aerosol delivery to children with stable asthma shows equivalent percentages of total lung deposition of radiolabeled salbutamol aerosolized by either a neBulizer or a pMDI/holding chamber.
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Washing plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery
TL;DR: Household detergents offer a simple and practical solution to the problem of static on plastic spacers and significantly improve both in vitro and in vivo delivery of salbutamol.