J
John Douglas Mcpherson
Researcher at University of California, Davis
Publications - 216
Citations - 73141
John Douglas Mcpherson is an academic researcher from University of California, Davis. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 74, co-authored 199 publications receiving 67145 citations. Previous affiliations of John Douglas Mcpherson include National University of Singapore & Case Western Reserve University.
Papers
More filters
Journal ArticleDOI
High-plex spatial RNA profiling reveals cell type-specific biomarker expression during melanoma development.
Maija Ht Kiuru,Michelle Kriner,Samantha L. Wong,G. Zhu,G. Zhu,Jessica R. Terrell,Qian Li,Margaret L. Hoang,Joseph M. Beechem,John Douglas Mcpherson +9 more
TL;DR: In this paper, the authors used spatial transcript profiling that maintains the morphological tumor context to measure expression of >1,000 RNAs in situ in patient-derived formalin-fixed, paraffin-embedded tissue sections in primary melanoma and melanocytic nevi.
Journal ArticleDOI
Regional perturbation of gene transcription is associated with intrachromosomal rearrangements and gene fusion transcripts in high grade ovarian cancer
Paul M. Krzyzanowski,Fabrice Sircoulomb,Fouad Yousif,Josee Normand,Josee Normand,Jose La Rose,Kyle E. Francis,Fernando Suarez,Tim Beck,John Douglas Mcpherson,John Douglas Mcpherson,Lincoln Stein,Lincoln Stein,Robert Rottapel,Robert Rottapel +14 more
TL;DR: The association of gene fusion transcripts with neighboring gene overexpression supports rearrangements as mechanism through which cancer cells remodel their transcriptomes and identifies a new way to utilize gene fusions as indicators of regional expression changes in diseased cells with only transcriptomic data.
Posted ContentDOI
A Comprehensive Assessment of Somatic Mutation Calling in Cancer Genomes
Tyler Alioto,Sophia Derdak,Timothy Beck,Paul C. Boutros,Lawrence Bower,Ivo Buchhalter,Matthew D. Eldridge,Nicholas J. Harding,Lawrence E. Heisler,Eivind Hovig,David T. W. Jones,Andy G. Lynch,Sigve Nakken,Paolo Ribeca,Anne Sophie Sertier,Jared T. Simpson,Paul T. Spellman,Patrick S. Tarpey,Laurie Tonon,Daniel Vodak,Takafumi N. Yamaguchi,Sergi Beltran,Marc Dabad,Robert E. Denroche,Philip Ginsbach,Simon Heath,Emanuele Raineri,Charlotte Anderson,Benedikt Brors,Ruben M. Drews,Roland Eils,Akihiro Fujimoto,Francesc Castro Giner,Minghui He,Pablo H. Hennings-Yeomans,Barbara Hutter,Natalie Jäger,Rolf Kabbe,Cyriac Kandoth,Semin Lee,Louis Letourneau,Singer Ma,Hidewaki Nakagawa,Nagarajan Paramasivam,Anne-Marie Patch,Myron Peto,Matthias Schlesner,Sahil Seth,David Torrents,David A. Wheeler,Liu Xi,John Zhang,Daniela S. Gerhard,Víctor Quesada,Rafael Valdés-Mas,Marta Gut,Peter J. Campbell,Thomas J. Hudson,John Douglas Mcpherson,Xose S. Puente,Ivo Gut +60 more
TL;DR: It is concluded that somatic mutation calling remains an unsolved problem and critical issues that need to be addressed before this valuable technology can be routinely used to inform clinical decision-making are highlighted.
Journal ArticleDOI
Non-enzymic glycation of proteins: analysis of N-(1-deoxyhexitol-1-yl)amino acids by high-performance liquid chromatography.
TL;DR: A method for determining the extent of non-enzymic glycation of both lysyl and N-terminal residues of a protein is described and has been applied successfully to samples of human hemoglobin and human serum albumin.
Journal ArticleDOI
Future Promises and Concerns of Ubiquitous Next-Generation Sequencing.
TL;DR: Personal genomics has arrived and is already being used in the clinic, but significant privacy issues remain, however, and these are not widely understood.